Inhibition of KDM5B participates in immune microenvironment remodeling in pancreatic cancer by inducing STING expression.

Objective: This study aims to investigate the effect of lysine demethylase 5B (KDM5B)-mediated dimethyl-lysine 4 histone H3 (H3K4me2) demethylation on immune microenvironment remodeling in pancreatic cancer.

Methods: Pan 02 mouse pancreatic cancer cell lines were cultured and used to establish tumor model in vivo. RT-qPCR and Western blot were used to detect the expression of stimulator of interferon gene (STING) and KDM5B in pancreatic cancer tissues and Pan 02 cells.

Investigation of Pre-service Teachers' Conceptions of the Nature of Science Based on the LDA Model.

This study used the Latent Dirichlet Allocation (LDA) topic model to analyze pre-service teachers' views on the nature of science (NOS). This approach can be used to automate the classification of documents, and at the same time, the researcher does not need to deduce with a NOS framework prior to evaluation. Participants were 155 pre-service teachers studying at the Shandong Normal University in China.

Accurate potential energy surface of HS( ″) via extrapolation to the complete basis set limit and its use in dynamics study of reaction.

The single-sheeted potential energy surface (PES) of is developed based on the energies calculated by the multi-reference configuration interaction method including the Davidson correction. All the energies are first calculated using aug-cc-pVdZ and aug-cc-pV5dZ basis sets, which are then extrapolated to the complete basis set (CBS) limit. A switching function is developed to model the transition of to .

Diagnostic utility of plasma lncRNA small nucleolar RNA host gene 1 in patients with hepatocellular carcinoma.

Long non‑coding RNAs (lncRNAs) offer great potential as cancer biomarkers. Owing to the limited sensitivity and specificity of α‑fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma (HCC), the present study used an lncRNA microarray to screen aberrantly expressed lncRNAs in HCC tissues. Subsequently, the expression profile of the target lncRNAs was investigated in plasma from patients with HCC or hepatitis B virus‑positive chronic hepatitis and cirrhosis (HCH), as well as from healthy volunteers.

Third-harmonic generation from gold nanowires of rough surface considering classical nonlocal effect.

We demonstrate that the nonlocal dielectric response of metal, comparing with the traditional local model, will significantly boost the third-order harmonic generation (THG) from gold nanowires of rough surface by a factor of several orders of magnitude. The enhancement is probably due to the penetrated field into the fine nanostructures on the metal surface in nonlocal model. The anisotropy THG efficiency versus the angle of incidence is also demonstrated due to the inhomogeneous surface morphology.

Real-time reliable determination of binding kinetics of DNA hybridization using a multi-channel graphene biosensor.

Reliable determination of binding kinetics and affinity of DNA hybridization and single-base mismatches plays an essential role in systems biology, personalized and precision medicine. The standard tools are optical-based sensors that are difficult to operate in low cost and to miniaturize for high-throughput measurement. Biosensors based on nanowire field-effect transistors have been developed, but reliable and cost-effective fabrication remains a challenge.

Globally accurate potential energy surface for the ground-state HCS(XA') and its use in reaction dynamics.

A globally accurate many-body expansion potential energy surface is reported for HCS(XA') by fitting a wealth of accurate ab initio energies calculated at the multireference configuration interaction level using aug-cc-pVQZ and aug-cc-pV5Z basis sets via extrapolation to the complete basis set limit. The topographical features of the present potential energy surface are examined in detail and is in good agreement with the raw ab initio results, as well as other theoretical results available in literatures. By utilizing the potential energy surface of HCS(XA'), the dynamic studies of the C(P) + SH(XΠ) → H(S) + CS(X∑) reaction has been carried out using quasi-classical trajectory method.

State-to-State Quantum Dynamics of Reactions O((3)P) + HD (v = 0-1, j = 0) → OH+D and OD+H: Reaction Mechanism and Vibrational Excitation.

Time-dependent quantum wave packet dynamics calculations have been performed in order to characterize the dynamics and mechanism of O((3)P) + HD (v = 0-1, j = 0) → OH+D and OD+H reactive collisions using the adiabatic potential energy surface by Rogers et al. [J. Phys.

Graphene-Based Flexible and Transparent Tunable Capacitors.

We report a kind of electric field tunable transparent and flexible capacitor with the structure of graphene-Bi1.5MgNb1.5O7 (BMN)-graphene.

Graphene/Cu nanoparticle hybrids fabricated by chemical vapor deposition as surface-enhanced Raman scattering substrate for label-free detection of adenosine.

We present a graphene/Cu nanoparticle hybrids (G/CuNPs) system as a surface-enhanced Raman scattering (SERS) substrate for adenosine detection. The Cu nanoparticles wrapped by a monolayer graphene shell were directly synthesized on flat quartz by chemical vapor deposition in a mixture of methane and hydrogen. The G/CuNPs showed an excellent SERS enhancement activity for adenosine.