Publications by authors named "ShouZi Hu"
Introduction: Intrahepatic cholangiocarcinoma (ICC) is characterized by a dismal prognosis with limited therapeutic alternatives. To explore phosphatase and tension homolog (PTEN) as a biomarker for proteasome inhibition in ICC, we conducted a phase II trial to assess the second-line efficacy of bortezomib in PTEN-deficient advanced ICC patients.
Methods: A total of 130 patients with advanced ICC in our centre were screened by PTEN immunohistochemical staining between 1 July 2017, and 31 December 2021, and 16 patients were ultimately enrolled and treated with single-agent bortezomib 1.
Article Synopsis
- Modified Child-Pugh (MCP) and Albumin-bilirubin (ALBI) grades are simpler and more objective alternatives to the traditional Child-Pugh (CP) class for evaluating liver function in patients with Hepatocellular Carcinoma (HCC).
- A study involving 376 HCC patients treated with transcatheter arterial chemoembolization (TACE) showed that the MCP grade had a higher predictive accuracy for overall survival compared to both CP and ALBI grades.
- While most patients presented with CP class A disease, the MCP grade was able to identify three distinct prognostic groups, indicating that it may be a more effective stratification tool than the CP class or ALBI grade for these patients.
Objective: To identify genes associated with the clinicopathological features of colorectal cancer (CRC).
Methods: Gene expression profiles were downloaded and preprocessed by GEOquery and affy R packages, respectively. The limma package was applied to identify the differentially expressed genes (DEGs) in CRC.