[An experimental study of endothelin receptor A expression in brain tissue after subarachnoid hemorrhage in rabbits].

Objective: To discuss the relationship between the expression of endothelin receptor A (ETRA) in brain tissue and delayed neurological deficit (DND) after subarachnoid hemorrhage (SAH).

Methods: Thirty-one Japanese rabbits were divided into SAH group (n=15), saline group (n=10), puncture group (n=3), normal control group (n=3) randomly, and they subdivided into 1 hour, 3 days, 5 days, 7 days, 10 days subgroups in both SAH group and saline group. The SAH model was successfully reproduced by intracisternal injection of autologous arterial blood twice.

[Effect of drainage of the cerebrospinal fluid at the acute period of aneurysmal subarachnoid hemorrhage on the formation of hydrocephalus].

Objective: To discuss the effect of drainage of the cerebrospinal fluid (CSF) at acute period after aneurysmal subarachnoid hemorrhage (SAH) on the formation of hydrocephalus.

Methods: Eighty-four patients with aneurysmal SAH were randomly divided into two groups according to therapeutic regimen. Forty-two cases in specific treatment group were given intravascular embolism at the acute period of hemorrhage after a ruptured aneurysm, then CSF was drained immediately.

[The early diagnosis and therapy of aneurismal subarachnoid hemorrhage].

Objective: To discuss the early diagnostic methods and therapeutic principles of aneurysmal subarachnoid hemorrhage (SAH), and evaluate the therapeutic efficacy objectively.

Methods: Using neuro-imaging examinations combined with case history and clinical symptoms to make the early diagnosis of 96 case with aneurysmal SAH, and Guglielmi detachable microcoil (GDC) was utilized for early intracapsular embolization in the ruptured aneurysms. Efficient symptomatic treatment was done early after operation.