Beijing Da Xue Xue Bao Yi Xue Ban
August 2008
Objective: To find a best synthesis method of diethyl N-[p-(methylamino)benzoyl]-L-glutamate(1).
Methods: Using diethyl N-(p- aminobenzoyl)-L-glutamate (2) as a starting material via a one-pot process of benzylation and methylation, the diethyl N-[p-(methylamino)benzoyl ]-L-glutamate (3) is prepared in high yield. Then compound 1 was conveniently obtained from debenzylation of compound 3 by Pd/C.