Study on the safety and effectiveness of low-dose vs. regular-dose fondaparinux in preventing venous thromboembolism prophylaxis following total knee arthroplasty.

Background: This study aims to evaluate the effectiveness and safety of low-dose (1.5 mg) fondaparinux for venous thromboembolism (VTE) prophylaxis in patients post-total knee arthroplasty (TKA).

Methods: We retrospectively identified 314 patients who carried out the primary TKAs and received fondaparinux for VTE chemoprophylaxis between July 2020 and December 2021.

[Change of autophagy in endplate chondrocytes of rats during aging process].

Objective: To explore the expression and significance of autophagy in endplate cartilage of rats during aging process.

Methods: The end-plate chondrocytes were isolated from 3, 6 and 12-month SD rats respectively. And the natural culture and rapamycin groups were assigned.

[Autophagy expression and its significance in chondrocytes from a degenerate model of human cervical endplate].

Objective: To explore the autophagy expression and examine its significance in chondrocytes in a degenerate model of human cervical vertebrae endplate.

Methods: Cartilage endplates were obtained from 48 hospitalized patients with cervical vertebral fracture or dislocation at our hospital between February 2012 to August 2012. They were divided into cervical spondylosis group with cervical spondylotic myelopathy (n = 31) and control group (n = 17).