[Surgical treatment for local recurrence of rectal carcinoma after operation].

Objective: To evaluate the value of reoperation for local recurrence of rectal carcinoma.

Methods: The data of 62 cases with post-operative local recurrence of rectal carcinoma were analyzed retrospectively.

Results: All the 62 patients received reoperation.

[Effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice].

Objective: To study the effect of angiogenesis inhibitor SU6668 on the growth and metastasis of gastric cancer in SCID mice.

Methods: Metastatic model was established by orthotopic implantation of histologically intact human tumor tissue into the gastric wall of SCID mice. Forty-eight mice were randomly divided into four groups, and saline, 5-FU, SU6668, and 5-FU plus SU6668 were administered by i.

[Expression of vascular endothelial growth factor C and survivin in gastric carcinoma and their clinical implications].

Objective: To investigate the expression of vascular endothelial growth factor C (VEGF-C) and survivin protein in human gastric carcinoma,and to evaluate their clinical implications.

Methods: The expressions of VEGF-C and survivin protein in tumor tissues,matched para- tumor tissues from 97 cases with gastric cancer and normal tissues form 20 normal controls,were determined by immunohistochemistry. Their relationships with clinicopathological parameters were analyzed.

[Diagnosis and treatment of benign duodenal tumor].

Objective: To investigate the diagnosis and treatment of benign duodenal tumor.

Methods: Clinical data of 14 patients with benign duodenal tumor confirmed pathologically or by operation from Oct.1988 to Oct.

Clinical significance of preoperative regional intra-arterial infusion chemotherapy for advanced gastric cancer.

Aim: Preoperative intra-arterial infusion chemotherapy could increase the radical resection rate of advanced gastric cancer, but its effect on the long-term survival has not been assessed. This study was designed to evaluate the clinical significance of preoperative intra-arterial infusion chemotherapy for advanced gastric cancer.

Methods: Clinicopathological data of 91 patients who underwent curative resection for advanced gastric cancer were collected.

Detection of serum tumor markers in the diagnosis and treatment of patients with pancreatic cancer.

Background: Although a variety of tumor markers are available for diagnosis of pancreatic cancer, their sensitivity and specificity have not yet been ideal. The aims of this study was to detect a panel of serum tumor markers and to evaluate their significance in the diagnosis and prognosis of pancreatic cancer patients.

Methods: Eight serum tumor markers including AFP, CEA, CA-50, CA72-4, CA-125, CA153, CA19-9 and CA242 were detected in 129 patients with pancreatic cancer by using chemiluminescence immunoassay, immunofluorescence assay and immunoradiometric assay, respectively.

Clinical characteristics and management of patients with early acute severe pancreatitis: experience from a medical center in China.

Aim: To study clinical characteristics and management of patients with early severe acute pancreatitis (ESAP).

Methods: Data of 297 patients with severe acute pancreatitis (SAP) admitted to our hospital within 72 h after onset of symptoms from January 1991 to June 2003 were reviewed for the occurrence and development of early severe acute pancreatitis (ESAP). ESAP was defined as presence of organ dysfunction within 72 h after onset of symptoms.

[Biological behavior of cardial cancer and its effect on surgical management].

Objective: To study the biological behavior of cardial cancer and its influence on surgical management.

Methods: Complete clinicopathologic data of 46 cases with cardial cancer undergoing radical gastrectomy was investigated retrospectively. The relationships between tumor Borrmann type, depth of invasion, growth pattern, lymph node metastasis and 5-year survival rate postoperative were analyzed.

Enteral nutrition in treatment of severe acute pancreatitis.

Objective: To observe the role and the timing of EN in the treatment of patients with severe acute pancreatitis (SAP).

Methods: Eleven patients with severe acute pancreatitis underwent systemic nutrition support were studied. EN was given through jejunostomy tube (or Bengmark tube) after a period of PN maintenance.

Effect of preoperative regional artery chemotherapy on proliferation and apoptosis of gastric carcinoma cells.

Aim: To study the effects of preoperative regional artery chemotherapy (PRACT) in inducing growth inhibition and apoptosis of gastric carcinoma (GC) cells.

Methods: TUNEL (terminal-deoxynucleotidyl-transferase TdT-mediated dUTP-fluorescein and labeling) method and immunohistochemical techniques were used to detect the state of apoptosis and proliferation of GC cells in histopathologic sections. A total of 110 cases of GC and 68 cases of metastatic lymph node with or without PRACT were adopted.