Insight into the molecular mechanism of miR-192 regulating resistance in piglets.

MicroRNAs (miRNAs) have important roles in many cellular processes, including cell proliferation, growth and development, and disease control. Previous study demonstrated that the expression of two highly homologous miRNAs (miR-192 and miR-215) was up-regulated in weaned piglets with F18 infection. However, the potential molecular mechanism of miR-192 in regulating infection remains unclear in pigs.

New insights into the codon usage patterns of the bactericidal/permeability-increasing (BPI) gene across nine species.

Bactericidal/permeability-increasing (BPI) protein is a member of a new generation of proteins known as super-antibiotics that are implicated as endotoxin neutralising agents. Non-uniform usage of synonymous codons for a specific amino acid during translation of a protein is known as codon usage bias (CUB). Analysis of CUB and compositional dynamics of coding sequences could contribute to a better understanding of the molecular mechanism and the evolution of a particular gene.