A review of epidemiology, diagnosis, and management of Mpox: The role of One Health.

Human monkeypox (Mpox) is an emerging zoonotic disease. Its clinical features are similar to but less severe than those of smallpox. The etiology of this disease is the monkeypox virus.

Yellow light and ultrasound Dual-responsive strontium-doped zinc oxide composites for dental caries prevention and remineralization.

Dental caries is one of the most prevalent chronic infectious diseases, mainly due to acid production by bacteria in the plaque biofilm, leading to enamel demineralization, tooth defects and pulpitis. Most of the current treatments are invasive and do not combine restoration of dental tissues, resolution of tooth staining or prevention of dental caries. In this study, a polydopamine (PDA)-encapsulated strontium-doped zinc oxide composite (Sr-ZnO@PDA, denoted as SZ@PDA) has been developed for caries prevention and remineralization.

Photo-generating Type-I ROS and aryl radicals by mitochondrial-targeting oxime-ester photogenerator for pyroptosis-mediated anti-hypoxia photoimmunotherapy.

Pyroptosis is an inflammatory form of programmed cell death with great potential in cancer immunotherapies. Photodynamic therapy (PDT) represents a promising treatment modality to trigger pyroptosis. However, the hypoxic microenvironment inside the tumors often induces limited therapeutic efficacy.

Low Serum Cholinesterase Levels Predict Poor Prognosis in Patients with Ovarian Cancer.

Objective: Previous studies reported that low cholinesterase (ChE) levels were associated with poor prognosis in various cancers, including bladder, pancreatic, lung, and colorectal cancers. This study aimed to evaluate the clinical significance of serum ChE levels as a prognostic biomarker in ovarian cancer.

Materials And Methods: A retrospective cohort analysis was conducted on 168 patients diagnosed with epithelial ovarian cancer at the Suzhou Ninth People's Hospital from 2019 to 2020.

Comparative Efficacy of NAFLD Therapies and Biomarker Associations: A Meta-Analysis Based on Liver Fat Content.

Background And Aims: This study aims to conduct a comprehensive quantitative analysis of various nonalcoholic fatty liver disease (NAFLD) therapeutics, utilizing magnetic resonance (MR)-detected liver fat content (LFC) as the efficacy endpoint, and to identify biomarkers correlated with changes in LFC based on published literature.

Methods: We performed a systematic search of public databases for placebo-controlled randomized trials on NAFLD up to September 29, 2023. A random-effects meta-analysis was employed to assess efficacy differences between drugs with various mechanisms and placebo.

Long-Term Impacts of Global Solid Biofuel Emissions on Ambient Air Quality and Human Health for 2000-2019.

Globally, solid biofuels (SB) have been widely used for household cooking and energy production for decades due to electricity shortages and socio-economic barriers to adopting renewable energy alternatives. This has detrimental effects on air quality, human health, and climate through trace gas and aerosol emissions. Despite numerous studies, the long-term consequences of SB emissions remain poorly understood.

Advancements in 3D printing technologies for personalized treatment of osteonecrosis of the femoral head.

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly in orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on the innovative application of 3D printing in addressing the challenges of osteonecrosis of the femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, 3D printing offers precise localization of necrotic areas and the ability to create personalized implants.

NIR-triggered and glucose-powered hollow mesoporous Mo-based single-atom nanozymes for cascade chemodynamic diabetic infection therapy.

Diabetic infections/wounds remain to be a threatening challenge as it seriously leads to lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) of diabetic infection, but is extremely restricted by the near-neutral pH and insufficient HO levels in physiological conditions. Herein, we innovated a hollow mesoporous molybdenum single-atom nanozyme (HMMo-zyme) featured with catalytic activity, photothermal performance and drug delivery properties for more effective antibacterial therapeutic in diabetic conditions.

Identification of novel components of the Ced and Ups systems in REY15A.

In cells, transcription of the Ups (UV-inducible pili of ) and Ced (Crenarchaeal system for exchange of DNA) genes is highly induced by DNA damage, and the two systems play key roles in pili-mediated cell aggregation and chromosomal DNA import, respectively. Ups is composed of UpsA, UpsB, UpsE, and UpsF, while Ced is composed of CedA, CedA1, CedA2, and CedB. So far, how DNA is transported by these systems is far from clear.

A new type of ArsR transcriptional repressor controls transcription of the arsenic resistance operon of SM-1.

Arsenic is the most common toxic metalloid in the environment. Nearly all organisms have genes for arsenic detoxification. Arsenic detoxification genes are frequently organized in chromosomal or plasmid-encoded arsenic resistance () operons, which are commonly regulated by members of the ArsR transcriptional repressors.

Turmeric-Induced Liver Injury.

Turmeric and its active compound, curcumin, has gained popularity as an herbal supplement due to its anti-inflammatory properties. However, the lack of standardized regulation for herbal supplements raises concerns about potential side effects and toxicity. This case report presents a 53-year-old woman with Behçet disease who developed biopsy-proven drug-induced liver injury (DILI) after initiating a turmeric supplement, with resolution of laboratory abnormalities after a positive supplement de-challenge.

Prognostic Significance of Homocysteine Levels in Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Propensity Score Matching and Weighting Analysis.

Background: Elevated homocysteine (Hcy) levels have been linked to poorer outcomes in acute coronary syndrome. This study aimed to assess the predictive value of elevated Hcy levels for major adverse cardiac events (MACE) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).

Methods: This retrospective cohort study included 183 STEMI patients who underwent primary PCI at a tertiary university hospital in southern China from January 2020 to December 2021.

Association of the Platelets to High Density Lipoprotein Cholesterol Ratio and Risk of Heart Disease Events in Middle-Aged and Elderly Chinese Population: A Retrospective Cohort Study Utilizing the CHARLS Database.

Background: The association between the platelet to high-density lipoprotein cholesterol ratio (PHR) and the risk of a heart disease event remains unclear. This study aims to determine whether the PHR can identify individuals at high risk for heart disease events, with a particular focus on middle-aged and elderly Chinese individuals.

Methods: The retrospective cohort study encompassed 7188 middle-aged and elderly participants (>45 years) sourced from the China Health and Retirement Longitudinal Study (CHARLS) database.

CCL11 (Eotaxin) Promotes the Advancement of Aging-Related Cardiovascular Diseases.

Aging-related diseases, such as cardiovascular diseases (CVDs), neurodegeneration, cancer, etc., have become important factors that threaten the lifespans of older individuals. A chronic inflammatory response is closely related to aging-related diseases.

Exploring Potential Drug Targets in Multiple Cardiovascular Diseases: A Study Based on Proteome-Wide Mendelian Randomization and Colocalization Analysis.

Cardiovascular diseases (CVDs) encompass a group of diseases that affect the heart and/or blood vessels, making them the leading cause of global mortality. In our study, we performed proteome-wide Mendelian randomization (MR) and colocalization analyses to identify novel therapeutic protein targets for CVDs and evaluate the potential drug-related protein side effects. We conducted a comprehensive proteome-wide MR study to assess the causal relationship between plasma proteins and the risk of CVDs.

Case Report: Traumatic obturator hip dislocation with subtrochanteric fracture in an 8-year-old child.

Background: Obturator-type hip dislocation is a rare condition in pediatric patients, with the simultaneous occurrence of an ipsilateral subtrochanteric femoral fracture being exceptionally uncommon. Although various treatment methods have been described for hip dislocation or subtrochanteric femoral fractures, managing these injuries remains challenging due to the potential risk of femoral head avascular necrosis and concerns about fixation stability.

Case Presentation: An 8-year-old boy sustained a traumatic obturator hip dislocation and an ipsilateral subtrochanteric fracture following a fall from a height.

 sp. nov. (Coleoptera, Curculionidae, Scolytinae, Phloeosinini), a new insect pest of in China.

We describe herein a previously unknown species of bark beetle, Ning, , which was discovered in the Xingdoushan National Nature Reserve, Hubei Province, China. This new species can be distinguished from other species in the genus Chapuis, 1869 by its deeply emarginate compound eyes, coarse frontal and prothoracic surfaces, reticulate texture, and deeply V-shaped basal margin of the elytra. Phylogenetic analyses based on the cytochrome oxidase I (COI) and the large nuclear ribosomal subunit (28S) genes indicated that the new species represents an independent lineage with the closely related (Perris, 1885), to which it has a 95% similarity.

COLEC10: A potential tumor suppressor and prognostic biomarker in hepatocellular carcinoma through modulation of EMT and PI3K-AKT pathways.

Hepatocellular carcinoma (HCC) is a cancer with poor prognosis, underscoring the urgent need for enhanced detection and management. This study aimed to investigate the role of Collectin Subfamily Member 10 (COLEC10) in HCC, which was revealed to be associated with various diseases. Bioinformatics tools, including GEO, cBioPortal, and TCGA, were used to identify differentially expressed genes.

Neurodegenerative diseases and neuroinflammation-induced apoptosis.

Neuroinflammation represents a critical pathway in the brain for the clearance of foreign bodies and the maintenance of homeostasis. When the neuroinflammatory process is dysregulate, such as the over-activation of microglia, which results in the excessive accumulation of free oxygen and inflammatory factors in the brain, among other factors, it can lead to an imbalance in homeostasis and the development of various diseases. Recent research has indicated that the development of numerous neurodegenerative diseases is closely associated with neuroinflammation.

Association Between Visual Acuity and Incident Atherosclerotic Cardiovascular Disease: A Longitudinal Test of Mediators.

Background: Little is known about the prospective relationship between visual acuity (VA) and atherosclerotic cardiovascular disease (ASCVD) events and the extent to which this association is mediated via potential mediators. This study aims to investigate the relationship between VA and ASCVD events, including the mediation effects of potential factors.

Methods: A prospective study was conducted using data from 110,522 participants in the UK Biobank, all of whom had baseline visual acuity (VA) measurements collected between 2006 and 2010.

Exploring the Relationship Between Aggressive Behavior, Family Parenting Styles, and Self-Esteem Among Only-Child College Students in China: A Cross-Sectional Study.

Background: The prevalence of aggressive behavior among adolescents in higher education settings, particularly within the unique context of China's one-child policy, has become an increasingly significant issue. This study aims to elucidate the interplay between aggressive behaviors, parenting styles, and self-esteem among college students who are only children.

Methods: Conducted as a cross-sectional study from September 2022 to September 2023, the research involved a sample of students from four higher education institutions in Anhui Province, employing a convenience sampling method stratified by year of study and academic major.

A Bibliometric and Visual Analysis of Oliceridine Research (2013-2024).

Purpose: To explore and analyze the current research progress, hotspots, and future trends in oliceridine research using bibliometric methods.

Patients And Methods: We searched the Web of Science (WOS) database utilizing the keywords TS = ("oliceridine*" OR "TRV 130*" OR "TRV-130*" OR "olinvyk*" OR "TRV130*" OR "C22H31CIN2O2S*") for relevant research literature on oliceridine from its inception to June 16, 2024. Bibliometric methods were applied, and analysis software such as VOSviewer and CiteSpace were used to visualize the publication timeline, authors, countries and regions, keywords, sources of literature, research hotspots, and co-cited documents related to oliceridine.

Chlorinated Bithiophene Imide-Based n-Type Polymers: Synthesis, Structure-Property Correlations, and Applications in Organic Electronic Devices.

Developing electron-deficient (hetero)arenes with optimized geometries and electronic properties is imperative for advancing n-type polymers and organic electronic devices. We report here the design and synthesis of two chlorinated imide-functionalized electron-deficient heteroarenes, namely chlorine-substituted bithiophene imide (ClBTI) and its fused dimer (ClBTI2). The corresponding polymers show a near-planar framework, appropriate frontier molecular orbital levels, and good solubility.

Dual Chern Insulators with Electronic and Magnonic Edge States in Two-Dimensional Ferromagnets.

Chern insulator (CI) exhibits rich physics with great interest in both theory and experiment. Here, we focus on the honeycomb and kagome ferromagnets and demonstrate that coupling the nontrivial electronic and magnonic bands allows for the dual CIs, where the quantum anomalous Hall effect and its bosonic analogue, i.e.