Alteration of microRNA expression in lymphocytes in patients with first-episode schizophrenia.

Background: The development of schizophrenia is related to a combination of genetic and epigenomic factors. MicroRNAs (miRNAs) play a crucial role in epigenetic processes and are relevant to the onset and progression of schizophrenia. They can regulate target genes during the growth and development of neurons and can be affected by genetic and environmental factors associated with schizophrenia.

Association of healthy lifestyle and the incidence of atrial fibrillation in senior adults: a prospective cohort study.

Background: Limited evidence was available on the association of the integrated effect of multidimensional lifestyle factors with AF incidence among Chinese old adults. This cohort study was to examine the effect of combined lifestyle factors on AF risk among Chinese older adults.

Methods: A total of 3,253 adults aged 60 years or more from the Guangzhou Heart Study were successfully followed up.

Assessing the performance of QLQ-C30 in predicting all-cause mortality in community cancer patients.

Background: To evaluate the ability of QLQ-C30 in predicting mortality in community-based cancer patients in China.

Methods: A whole-cluster sampling method was adopted to enroll cancer patients in four communities in Shanghai from 2018 to 2019. The patients were surveyed using a questionnaire enquiring demographic information, cancer types, and QLQ-C30 scale.

Imaging predictors of progressive infarction in patients with anterior circulation small subcortical infarction.

Background: The purpose of the present study is to investigate the association between imaging characteristics and progressive infarction (PI) in patients with anterior circulation single subcortical infarction (ACSSI).

Methods: Between January 2020 and October 2022, we retrospectively enrolled 638 ACSSI patients admitted to the Stroke Unit of First Affiliated Hospital of Nanchang University within 48 h after symptom onset. Demographic characteristics, clinical information, laboratory data, and imaging features (the number of infarct slices and the maximal diameter of infarcts) were collected.

Pelvic vasectomy and its protective effects on rat testis function.

Background: Vasectomy is a commonly used male contraceptive method, but the choice of surgical technique can influence long-term reproductive health outcomes. Previous studies suggest that different vasectomy techniques may lead to varying degrees of tissue damage, oxidative stress, and endocrine dysfunction. However, there is limited research on how these techniques affect overall reproductive system function.

Efficacy and safety of postoperative adjuvant HAIC with FOLFOX combining PD-1 inhibitors in HCC patients with microvascular invasion: a propensity score matching analysis.

Purpose: To evaluate the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (PA-HAIC) plus programmed death-1 (PD-1) inhibitors versus PA-HAIC alone for hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI).

Methods: This retrospective study included HCC patients with MVI who were treated with either PA-HAIC or PA-HAIC plus PD-1 inhibitors between February 2021 and February 2024. The differences in baseline characteristics, disease-free survival (DFS), and overall survival (OS) were compared between the two groups before and after propensity score-matching (PSM).

Analyzing MASLD interventional clinical trial registration based on the ClinicalTrials.gov database.

Objective: With the rising incidence of MASLD, extensive drug research has been conducted in clinical trials. The study examined the design principles and research objectives of MASLD therapeutics, in order to offer guidance to clinical trial participants and decision makers.

Methods: By searching the clinical research trial data registered on clinicaltrials.

Safety and efficacy of lesion size index guided 50 W radiofrequency ablation in patients with paroxysmal atrial fibrillation.

Background: Pulmonary vein isolation (PVI) using conventional power (30-35 W) radiofrequency ablation (RFA) has been an effective treatment strategy for paroxysmal atrial fibrillation (PAF), but its longer duration may cause collateral damage to peripheral tissue including esophageal and phrenic nerve. High-power (HP) RFA, due to better transmural performance and shorter duration, may reduce the damage to adjacent tissue and is expected to be a safe and efficient ablation strategy.

Methods: In this retrospective cohort study, we included 259 patients with PAF who underwent lesion size index (LSI)-guided radiofrequency ablation.

Ketogenic diets and β-hydroxybutyrate in the prevention and treatment of diabetic kidney disease: current progress and future perspectives.

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease. Ketogenic diets (KD) is a high-fat, low-carbohydrate diet. KD produces ketone bodies to supplement energy in the case of insufficient glucose in the body.

Morphological and metabolic changes in Changshan Huyou (Citrus changshan-huyou) following natural tetraploidization.

Background: Polyploids in citrus are generally used to improve crop varieties. Changshan Huyou (Citrus changshan-huyou) is a native citrus species in China that is highly adaptable and has pharmaceutical value. However, the influence in Changshan Huyou following polyploidization remains unclear.

c-Kit cells that intercalate with crypt Lgr5 cells are distinctively multipotent in colonic epithelium renewal and repair.

The colonic crypts are principally composed by Lgr5 stem cells and deep crypt secretory (DCS) cells. c-Kit-expressing cells mark DCS cells and supply Wnt3, EGF, and Notch signals to support their neighboring crypt bottom-intermingled Lgr5 cells. However, the role of c-Kit cells beyond supporting Lgr5 cells in colonic epithelium remains unexplored.

Integrated single-cell and spatial transcriptomic profiling reveals that CD177 Tregs enhance immunosuppression through apoptosis and resistance to immunotherapy in hepatocellular carcinoma.

Regulatory T cells (Tregs), an immunosuppressive subpopulation of CD4 T cells, are prevalent in tumor tissues, where they impede effective antitumor immune responses and represent potential targets for immunotherapy. However, targeting tumor-infiltrating Treg cells (TiTregs) remains challenging. In this study, we identified CD177 as a biomarker specifically expressed in TiTregs but not in adjacent or peripheral Treg cells through single-cell transcriptome sequencing combined with a stringent screening strategy.

Role of GPX3+ astrocytes in breast cancer brain metastasis activated by circulating tumor cell exosomes.

Brain metastasis from breast cancer (BMBC) contributes significantly to mortality, yet its mechanisms remain unclear. This study investigates the activation of GPX3+ astrocytes by circulating tumor cell (CTC)-derived exosomes in the metastatic process. Using a mouse model of BMBC, we performed single-cell RNA sequencing (scRNA-seq) and metabolomics to explore the role of GPX3+ astrocytes in the brain microenvironment.

Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis.

Cancer cells with RAS mutations exhibit enhanced autophagy, essential for their proliferation and survival, making it a potential target for therapeutic intervention. However, the regulatory differences between RAS-induced autophagy and physiological autophagy remain poorly understood, complicating the development of cancer-specific anti-autophagy treatments. In this study, we identified a form of non-canonical autophagy induced by oncogenic KRAS expression, termed RAS-induced non-canonical autophagy via ATG8ylation (RINCAA).

STAT1 mediates the pro-inflammatory role of GBP5 in colitis.

Previous studies establish guanylate binding protein 5 (GBP5) as a driver in the development of inflammatory bowel diseases (IBDs). Here, we aim to elucidate the mechanism underlying the pro-inflammatory role of GBP5. We observe that loss of Gbp5 causes reduced colonic inflammation and decreased numbers of innate lymphoid cells (ILCs) in colitis mice.

Wideband filtering antenna loading U-shaped parasitic patches based on characteristic mode analysis.

A wideband filtering antenna loading with U-shaped parasitic patches (UPP) is proposed by the characteristic mode analysis (CMA). The antenna is consisted of two dielectric substrates, one of which is printed with an eight-sawteeth patch, four single-sawteeth patches and two pairs of U-shaped parasitic patches. The sawteeth structures enable the two distinct characteristic modes to be closer with a smaller frequency space while allowing them to coexist within the operating frequency band, significantly enhancing the bandwidth.

Epiconone, one novel cyclohexenone from endophytic fungi Epicoccum sp. 1-042.

Targeting drug-resistant Acinetobacter baumannii, two fungal strains, Epicoccum sp. 1-042 and Penicillium sp. 19-115, were identified from 35 fungi isolated from Tibet.

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype.

The capacity to regenerate myelin in the central nervous system diminishes with age. This decline is particularly evident in multiple sclerosis (MS), a chronic demyelinating disease. Whether cellular senescence, a hallmark of aging, contributes to remyelination impairment remains unknown.

Lighting up metal nanoclusters by the HO-dictated electron relaxation dynamics.

The modulation of traps has found attractive attention to optimize the performance of luminescent materials, while the understanding of trap-involved photoluminescence management of metal nanoclusters greatly lags behind, thus extensively impeding their increasing acceptance as the promising chromophores. Here, we report an efficient passivation of the structural oxygen vacancies in AuAg nanoclusters by leveraging the HO molecules, achieving a sensitive color tuning from 536 to 480 nm and remarkably boosting photoluminescence quantum yield from 5.3% (trap-state emission) to 91.

IGF1R activates FOXP3-β-catenin signaling to promote breast cancer development.

Purpose: Forkhead box P3 (FOXP3), a key marker of regulatory T cells (Tregs), is crucial for Treg differentiation and development. Emerging evidence suggests that FOXP3 is also expressed in various tumor cells; however, its role in tumor progression remains controversial. This study aimed to elucidate the impact of FOXP3 on breast cancer development.

Semaglutide, a glucagon-like peptide-1 receptor agonist, inhibits oral squamous cell carcinoma growth through P38 MAPK signaling pathway.

Aims: Researches have shown that diabetes mellitus (DM) can promote the risk and progression of oral squamous cell carcinoma (OSCC). Semaglutide, a glucagon-like peptide-1 receptor agonist, is currently employed to treat type 2 diabetes mellitus (T2DM) and obesity. This study intends to explore the potential effects and mechanism of Semaglutide on OSCC.