Prognostic Value of Changes in Combined Child-Pugh Class and ALBI Grade in Hepatocellular Carcinoma Treated with Transcatheter Intra-Arterial Therapy Plus Targeted Therapy and PD-(L)1 Inhibitors.

Purpose: This study aims to investigate liver function changes in hepatocellular carcinoma (HCC) patients treated with transcatheter intra-arterial therapy plus molecular targeted agents and programmed cell death-1 (ligand-1) inhibitors, and evaluate the prognostic significance of the combination of Child-Pugh (CP) class and albumin-bilirubin (ALBI) grade (CP/ALBI).

Methods: This is a retrospective study. A total of 149 patients from 2019 to 2023 in China were included.

Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk.

Coronary artery disease (CAD) remains the leading cause of mortality worldwide, driven by both lifestyle factors and genetic predisposition. Large-scale population genetic studies have greatly enhanced our understanding of the genetic underpinnings of CAD and facilitated the discovery of disease-associated genes. Noncoding RNAs, such as circular RNAs (circRNAs) and microRNAs (miRNAs), play crucial roles in the regulation of these genes.

SE(3)-Equivariant Ternary Complex Prediction Towards Target Protein Degradation.

Targeted protein degradation (TPD) induced by small molecules has emerged as a rapidly evolving modality in drug discovery, targeting proteins traditionally considered "undruggable". Proteolysis-targeting chimeras (PROTACs) and molecular glue degraders (MGDs) are the primary small molecules that induce TPD. Both types of molecules form a ternary complex linking an E3 ligase with a target protein, a crucial step for drug discovery.

Geodesign in the era of artificial intelligence.

This paper explores the evolution of Geodesign in addressing spatial and environmental challenges from its early foundations to the recent integration of artificial intelligence (AI). AI enhances existing Geodesign methods by automating spatial data analysis, improving land use classification, refining heat island effect assessment, optimizing energy use, facilitating green infrastructure planning, and generating design scenarios. Despite the transformative potential of AI in Geodesign, challenges related to data quality, model interpretability, and ethical concerns such as privacy and bias persist.

Corrigendum: Saturation mapping of a major effect QTL for stripe rust resistance on wheat chromosome 2B in cultivar Napo 63 using SNP genotyping arrays.

[This corrects the article DOI: 10.3389/fpls.2017.

Mechanisms underlining R-loop biology and implications for human disease.

R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play crucial roles in regulating gene expression, DNA replication, and transcription processes. However, R-loops have also been increasingly described as highly deleterious, causing genomic instability and DNA damage.

Bench Surgery with Robot-assisted Kidney Autotransplantation for Complex Kidney Tumors: Technique and Outcomes from a Single Center.

Background And Objective: Bench surgery (BenS) with kidney autotransplantation serves as an alternative to nephron-sparing surgery (NSS) for patients harboring high-complexity renal tumors that are ineligible for in situ partial nephrectomy (PN). However, the experience of BenS with robot-assisted kidney autotransplantation (RAKAT) has been scarce in such cases. Here, we describe the operative techniques, and functional and oncological outcomes of BenS with RAKAT.

A Bibliometric Analysis of the Application of Brain-Computer Interface in Rehabilitation Medicine Over the Past 20 Years.

Objective: This study aims to conduct a bibliometric analysis of the application of brain- computer interface (BCI) in rehabilitation medicine, assessing the current state, developmental trends, and future potential of this field. By systematically analyzing relevant literature, we seek to identify key research themes and enhance understanding of BCI technology in rehabilitation.

Methods: We utilized bibliometric analysis tools such as VOSviewer and CiteSpace to screen and analyze 426 relevant articles from the Web of Science Core Collection (WoSCC) database.

Genetic variation in RYR1 is associated with heart failure progression and mortality in a diverse patient population.

Introduction: Heart failure (HF) is a highly prevalent disease affecting roughly 7 million Americans. A transcriptome-wide analysis revealed upregulation in HF patients with severe pulmonary hypertension. Therefore, we aimed to further characterize the role of in HF progression and mortality.

SCGB1A1 as a Key Regulator of Splenic Immune Dysfunction in COPD: Insights From a Murine Model.

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a chronic inflammatory disorder characterized by irreversible airflow limitation and systemic immune impacts. COPD patients demonstrate an increased susceptibility to sepsis and septic shock, underscoring the importance of understanding its effects on splenic function.

Methods: A rat COPD model was established using lipopolysaccharide (LPS) and cigarette smoke exposure.

The impact of lymph node dissection on stage I ovarian endometrioid carcinoma: A US-China Comparative Analysis.

This study investigated the prognostic impact of lymph node dissection (LND) in patients with stage I ovarian endometrioid carcinoma (OEC) and aimed to identify the optimal LND range for improved survival. By analyzing data from the Surveillance, Epidemiology, and End Results (SEER) database conducted in USA and NUWA database in China, we found that patients who underwent LND in the SEER cohort exhibited significantly improved long-term survival rates compared to those who did not undergo LND, while the difference was not statistically significant in the NUWA cohort. Cox regression and restricted cubic spline analyses indicated an inverted U-shaped association between the number of LNDs and hazard ratios, identifying 29-34 lymph nodes as the optimal range.

Effectiveness Evaluation on Network Fracturing in Ultra-Deep and Extremely Thick Reservoirs in Kuqa Piedmont-A Case Study of Well KS2-A.

In the Keshen Gas Field in Kuqa Piedmont, the Cretaceous Bashijiqike formation is the main producing layer. The deepest exploratory wells exceed 8000 m, with reservoir pressures reaching 150 MPa, temperatures peaking at 190 °C, and formation thicknesses ranging from 100 to 300 m. The extreme operating conditions and well-controlled risks limit the testing methods after stimulation.

Designed Fabrication of SnO/InO/C Electrochemical Sensors for Coolant Leakage Detection in Energy Storage Systems.

The liquid cooling system for lithium iron phosphate battery modules usually faces the threat of coolant leakage, which would dramatically affect the heat transfer performance, safety, and efficiency of the energy storage system. Herein, electrochemical sensing technology has been first employed to detect coolant leakage. Specifically, ethanol is selected as the additive reagent and used as the main tested substance, and the sensors indirectly identify the coolant leakage by detecting the leaked ethanol.

Intersecting impact of CAG repeat and Huntingtin knockout in stem cell-derived cortical neurons.

Huntington's Disease (HD) is caused by a CAG repeat expansion in the gene encoding Huntingtin (HTT . While normal HTT function appears impacted by the mutation, the specific pathways unique to CAG repeat expansion versus loss of normal function are unclear. To understand the impact of the CAG repeat expansion, we evaluated biological signatures of HTT knockout ( KO) versus those that occur from the CAG repeat expansion by applying multi-omics, live cell imaging, survival analysis and a novel feature-based pipeline to study cortical neurons (eCNs) derived from an isogenic human embryonic stem cell series (RUES2).

Context-Dependent and Gene-Specific Role of Chromatin Architecture Mediated by Histone Modifiers and Loop-extrusion Machinery.

Loop-extrusion machinery, comprising the cohesin complex and CCCTC-binding factor CTCF, organizes the interphase chromosomes into topologically associating domains (TADs) and loops, but acute depletion of components of this machinery results in variable transcriptional changes in different cell types, highlighting the complex relationship between chromatin organization and gene regulation. Here, we systematically investigated the role of 3D genome architecture in gene regulation in mouse embryonic stem cells under various perturbation conditions. We found that acute depletion of cohesin or CTCF disrupts the formation of TADs, but affects gene regulation in a gene-specific and context-dependent manner.

Characterizing massa intermedia morphology in schizophrenia: associations with aging, neuropsychological functioning, and atypical hippocampal development.

The massa intermedia (MI) is a midline structure connecting the left and right thalamus that typically develops during the 2 trimester of pregnancy. Missing and smaller MI has been linked to neurodevelopmental disorders, including schizophrenia (SZ), and subtle deficits in cognition. However, findings are inconsistent and the association between MI and other anatomical variants linked to atypical brain development in SZ, including incomplete hippocampal inversion (IHI), is unclear.

TEMI: Tissue Expansion Mass Spectrometry Imaging.

The spatial distribution of diverse biomolecules in multicellular organisms is essential for their physiological functions. High-throughput mapping of biomolecules is crucial for both basic and medical research, and requires high scanning speed, spatial resolution, and chemical sensitivity. Here, we developed a Tissue Expansion method compatible with matrix-assisted laser desorption/ionization Mass spectrometry Imaging (TEMI).

Performance of Four Screening Tools for Identifying Obstructive Sleep Apnea Among Patients with Insomnia.

Purpose: Co-morbid insomnia and sleep apnea are common in clinical practice. The existing OSA screening tools have not been fully validated in insomnia populations, and items measuring daytime function may be interfered with the presence of insomnia. This study aims to validate the performance of four commonly used OSA screening tools among individuals with and without insomnia.

Transapical Transcatheter Aortic Valve Implantation with the J-Valve System in Aortic Regurgitation.

Background: Aortic regurgitation (AR) is a condition associated with significant morbidity and mortality, particularly in severe cases. The J-Valve system, next-generation transcatheter heart valve, may overcome the procedural challenges associated with treating pure AR. This study reported the outcome of use of the J-Valve for treatment of AR.

PD-1/PD-L1 Inhibitors Plus Chemotherapy Versus Chemotherapy Alone as First-Line Therapy for Patients With Unfavorable Cancer of Unknown Primary: A Multicenter, Retrospective Cohort Study.

This multicenter study aimed to investigate the efficacy and safety of PD-1/PD-L1 inhibitors plus chemotherapy (ICI-Chemo group) versus chemotherapy alone (Chemo group) for patients with cancer of unknown primary (CUP) in the first-line setting. We included patients with unfavorable CUP across four medical centers in China. Between January 2014 and December 2023, 117 patients were enrolled: 46 patients in the ICI-Chemo group and 71 patients in the Chemo group.

MHZ3: a key regulator of ethylene signaling in rice.

The plant hormone ethylene regulates plant growth, development, and stress responses. Recent studies on early signaling events following ethylene perception in rice () have identified MAO HU ZI 3 (MHZ3) as a stabilizer of the ethylene receptors ETHYLENE RESPONSE SENSOR 2 (OsERS2) and ETHYLENE RECEPTOR 2 (OsETR2). MHZ3 ensures the interaction of these receptors with CONSTITUTIVE TRIPLE RESPONSE 2 (OsCTR2), thereby maintaining OsCTR2 activity.

A 6.49-Mb inversion associated with the purple embryo spot trait in potato.

Unlabelled: The embryo spot trait leads to a deep purple or reddish coloration at the base of the cotyledons of the embryo, visible on both sides of flat potato () seeds. This trait has long been used by potato researchers and breeders as a morphological marker during dihaploid induction. The formation of embryo spots reflects the accumulation of anthocyanins, but the genetic basis of this trait remains unclear.

Accurate volume image reconstruction for digital breast tomosynthesis with directional-gradient and pixel sparsity regularization.

Purpose: We aim to develop accurate volumetric quantitative imaging of iodinated contrast agent (ICA) in contrast-enhanced digital breast tomosynthesis (DBT).

Approach: The two main components of the approach are the use of a dual-energy DBT (DE-DBT) scan and the development of an optimization-based algorithm that can yield accurate images with isotropic resolution. The image reconstruction algorithm exploits sparsity in the subject's directional derivative magnitudes, and it also performs direct sparsity regularization to help confine the reconstruction to the true support of the subject.