Potential mechanism of circKIAA1429 accelerating the progression of hepatocellular carcinoma.

Background: This study investigates the underlying mechanism of circKIAA1429 (hsa_circ_0084922) in hepatocellular carcinoma (HCC) progression.

Methods: circKIAA1429, SETD1A, NAP1L3, and GLIS2 expressions in HCC cells were detected by RT-qPCR or western blot. The stability of circKIAA1429 was tested after treatment with actinomycin D and Rnase R enzyme.

X-chromosome-linked miR-542-5p as a key regulator of sex disparity in rats with adjuvant-induced arthritis by promoting Th17 differentiation.

Background: Studies have indicated that X-linked microRNAs (miRNAs) play a role in the pathogenesis of rheumatoid arthritis (RA) and its gender-specific differences. However, research on specific miRNAs remains limited. This study aims to investigate the possible role of X-linked miR-542-5p in RA pathogenesis and gender differences.

Nanomedicine's shining armor: understanding and leveraging the metal-phenolic networks.

Metal-phenolic networks (MPNs), which comprise supramolecular amorphous networks formed by interlinking polyphenols with metal ions, garner escalating interest within the realm of nanomedicine. Presently, a comprehensive synthesis of the cumulative research advancements and utilizations of MPNs in nanomedicine remains absent. Thus, this review endeavors to firstly delineate the characteristic polyphenols, metal ions, and their intricate interaction modalities within MPNs.

Diazepam exposure associated with an increased risk of acute kidney injury in children: an observational cohort study.

Background: Potentially nephrotoxic drugs play an important role in acute kidney injury (AKI) in children. In the previous pharmacovigilance study, we found a statistical correlation between diazepam and AKI in children, but the causality needs to be further verified.

Methods: An observational cohort study was conducted to investigate the association between diazepam exposure and the risk of AKI in hospitalized children.

High-dimensional deconstruction of HNSC reveals clinically distinct cellular states and ecosystems that are associated with prognosis and therapy response.

Background: Characterizing the variety of cell types in the tumor microenvironment (TME) and their organization into cellular communities is vital for elucidating the biological diversity of cancer and informing therapeutic strategies.

Methods: Here, we employed a machine learning-based algorithm framework, EcoTyper, to analyze single-cell transcriptomes from 139 patients with head and neck squamous cell carcinoma (HNSC)and gene expression profiles from 983 additional HNSC patients, aiming to delineate the fundamental cell states and ecosystems integral to HNSC.

Results: A diverse landscape of 66 cell states and 9 ecosystems within the HNSC microenvironment was identified, revealing classical cell types while also expanding upon previous immune classifications.

Ergonomic interventions to improve musculoskeletal disorders among vehicle assembly workers: a one-year longitudinal study.

Background: Musculoskeletal disorders (MSDs) constitute a significant challenge in the realm of occupational health, especially in the manufacturing sector, necessitating the development of efficacious intervention strategies to enhance musculoskeletal health and reduce the incidence of MSDs. The present study is designed to assess the efficacy of a comprehensive ergonomic intervention, specifically tailored to diminish ergonomic risk factors and the prevalence of MSDs among workers engaged in vehicle assembly line operations.

Method: This interventional study, conducted over a one-year period, was implemented among assembly line workers within a rail bound vehicle manufacturing shop.

Association between cancer-associated fibroblasts and prognosis of neoadjuvant chemoradiotherapy in esophageal squamous cell carcinoma: a bioinformatics analysis based on single-cell RNA sequencing.

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive subtype of esophageal cancer, posing a significant mortality and economic burden, especially in East and Southeast Asia. Current therapeutic strategies have limitations in improving patient survival, particularly regarding disease progression and resistance. This study aimed to investigate the impact of neoadjuvant chemoradiotherapy (NCRT) on the ESCC microenvironment.

The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice.

Phage therapy is an effective strategy to combat multidrug resistance in bacteria and has been increasingly utilized to protect animals from bacterial infections. This study involved the isolation and purification of a novel myoviruses phage, vB_AceP_PAc, from a drug-resistant bacterial strain Aeromonas caviae. Genome sequence analysis based on nucleotide sequences revealed that vB_AceP_PAc shared significant similarity with the genomes of 10 other Aeromonas phages, with the highest coverage rate of 52% with phiA047.

Effects of dynamic neuromuscular stabilization training on the core muscle contractility and standing postural control in patients with chronic low back pain: a randomized controlled trial.

Background: Patients with chronic low back pain (CLBP) usually demonstrate poor postural control due to impaired core muscle function. Dynamic neuromuscular stabilization (DNS) is based on developmental kinesiology principles, utilizing infant motor patterns to treat motor disorders. DNS has been shown to improve postural control in cerebral palsy patients by activating core muscle.

Predictors of occult lymph node metastasis in clinical T1 lung adenocarcinoma: a retrospective dual-center study.

Background: The optimal surgical strategy for lymph node dissection in lung adenocarcinoma remains controversial. Accurate predicting occult lymph node metastasis (OLNM) in patients with clinical T1 lung adenocarcinoma is essential for optimizing treatment decisions and improving patient outcomes. This study analyzes the relationship between anaplastic lymphoma kinase (ALK) status, clinicopathological characteristics, computed tomography (CT) features, and OLNM in patients with clinical T1 lung adenocarcinoma.

Specific detection of Brucella spp. from slaughter-aged livestock using a dual priming oligonucleotide system.

Background: Brucella spp. are Gram-negative bacteria causing brucellosis, a major zoonotic disease affecting animals and humans. Annually, over 500,000 human cases are reported globally, with many undiagnosed due to nonspecific symptoms and diagnostic challenges.

Associations of the C-reactive protein-albumin-lymphocyte index with all-cause and cardiovascular mortality among individuals with cardiovascular disease: evidence from the NHANES 2001-2010.

Background: Evidence regarding the C-reactive protein‒albumin‒lymphocyte (CALLY) index and mortality risk in individuals with cardiovascular disease (CVD) is scarce. This study investigated the relationships of the CALLY index with all-cause and cardiovascular mortality risk in CVD patients among American adults.

Methods: This study enrolled 2183 CVD individuals from five NHANES cycles (2001-2010), and mortality outcomes were determined by linking the data to National Death Index (NDI) records up to December 31, 2019.

Impact of Maternal Exposure to Trace Metal Mixtures on Bone Mineral Density in Children Aged 3-6: Results from the Guangxi Zhuang Birth Cohort, China.

Prospective studies examining early maternal exposure to trace metal (TM) mixtures and their effects on offspring remain limited. We analyzed data regarding maternal plasma trace metal concentrations and bone mineral density (BMD) for 220 children aged 3-6 years from the Guangxi Zhuang Birth Cohort. Inductively coupled plasma-mass spectrometry was used to measure 22 trace metal concentrations-Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rb, Sr, Mo, Cd, Sb, Cs, Ba, W, Tl, Pb, and U-in maternal plasma samples collected before 13 weeks of gestation.

All-in-One: A Multifunctional Composite Biomimetic Cryogel for Coagulation Disorder Hemostasis and Infected Diabetic Wound Healing.

Traditional hemostatic materials are difficult to meet the needs of non-compressible bleeding and for coagulopathic patients. In addition, open wounds are susceptible to infection, and then develop into chronic wounds. However, the development of integrated dressings that do not depend on coagulation pathway and improve the microenvironment of chronic wounds remains a challenge.

Patient-Reported Outcomes for Patients with Previously Treated Small Cell Lung Cancer Receiving Tarlatamab: Results from the DeLLphi-301 Phase 2 Trial.

Introduction: Tarlatamab demonstrated a durable response and promising survival outcomes in patients with previously treated small cell lung cancer (SCLC) in the phase 2, open-label DeLLphi-301 trial. Patient-reported outcomes (PROs) were evaluated to assess the benefit-risk profile of tarlatamab.

Methods: Patients received tarlatamab intravenously every 2 weeks at a dose of 10 mg (regulatory approved dose) or 100-mg until progression or loss of benefit.

β-Nicotinamide mononucleotide blocks UVB-induced collagen reduction via regulation of ROS/MAPK/AP-1 and stimulation of mitochondrial proline biosynthesis.

β-Nicotinamide mononucleotide (NMN), as a precursor of long-lived protein co-factor nicotinamide adenine dinucleotide (NAD) in the human body, has demonstrated promising clinical value in treating photoaging and skin wounds. Previous research showed that NMN possessed significant skin protection against UVB-induced photoaging and promoted collagen synthesis. However, its potential mechanism remains unclear.

Annexin A1 regulates inflammatory-immune response and reduces pancreatic and extra- pancreatic injury during severe acute pancreatitis.

Severe acute pancreatitis (SAP) poses significant challenges due to its complex pathophysiology, which includes inflammatory-immune responses that cause considerable damage to both the pancreas and other tissues. In this study, we explored the role of Annexin A1 (Anxa1), a glucocorticoid-regulated protein recognized for its anti-inflammatory properties, in regulating inflammation during acute pancreatitis. Using flow cytometry, single-cell RNA sequencing, and gene expression analysis, we examined how Anxa1 expression is regulated in myeloid cells throughout acute pancreatitis, employing various animal models to evaluate the consequences of modulating Anxa1 on injuries induced by SAP.

TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.

Bladder cancer (BC) is one of the top ten most common tumors, with recurrence and metastasis being major causes of mortality among patients. A high recurrence rate is a hallmark of BC. Epithelial-mesenchymal transition (EMT) plays a role in the formation of cancer stem cells, tumor metastasis, and immune evasion.

STK31 drives tumor immune evasion through STAT3-IL-6 mediated CD8 T cell exhaustion.

Dysregulations in protein kinases significantly contribute to the initiation, progression, and drug resistance in non-small cell lung cancer (NSCLC). Identification of novel oncogenic drivers within the human kinome is crucial for targeted therapy. In this study, we conducted a comprehensive analysis of the TCGA database and literature, pinpointing 16 candidate genes in lung cancer exhibiting frequent dysregulation and limited research.

Serum 25-hydroxyvitamin D levels and peripheral blood eosinophil percentages as predictive indicators for eosinophilic chronic sinusitis with nasal polyps.

Purpose: Chronic rhinosinusitis (CRS) has a high incidence rate and different endotypes. Serum 25-hydroxyvitamin D (25(OH)D) deficiency is common in patients with eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP and nECRSwNP, respectively). This study explored the relationship between serum 25(OH)D levels and CRS risk and determined the value of combining serum 25(OH)D with peripheral blood markers in distinguishing between ECRSwNP and nECRSwNP.

Facile synthesis of ultratough conductive gels with swelling and freezing resistance for flexible sensor applications.

The application of flexible hydrogel sensors in extreme environments, such as low temperatures, underwater, or significant mechanical deformations, poses considerable challenges. Here, we present a simple one-pot method to fabricate ultra-tough, swelling- and freezing-resistant conductive organohydrogels without external conductive and freeze-resistant fillers. During gelation, by-products (CHNHCl, KCl) provide both conductivity and antifreeze properties, thus eliminating compatibility issues and dispersion challenges associated with external fillers.

The correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients.

To investigate the correlation between serum sex hormone levels and clear cell renal cell carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC and with simple renal cysts in our hospital from 2017 to 2023 were collected. The basic clinical data and serum sex hormone levels, including luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol(E), prolactin (PRL), progesterone(P), and testosterone (T), were compared between patients with ccRCC and patients with simple renal cysts.

Optimized UNet framework with a joint loss function for underwater image enhancement.

As the water economy advances and the concepts of water ecology protection and sustainable development take root in people's minds, underwater imaging equipment has made remarkable progress. However, due to various factors, underwater images still suffer from low quality. How to enhance the quality of underwater images so that people can understand them quickly has become a crucial issue.

Multiscale numerical investigation into the effects of rock content and rock particle size on the macroscopic and mesoscopic mechanical characteristics of soil rock mixture.

Soil-rock mixture is a typical two-phase composite material. The physicomechanical properties and relative quantities of each component greatly influence the macroscopic mechanical properties of the soil-rock mixture. This study takes the macroscopic and mesoscopic coupling perspective and uses the discrete element direct shear test as the main method to comprehensively investigate the effects of rock content and rock particle size on the mechanical properties of the soil-rock mixture.

Constructing a knowledge graph-driven intelligent data-enabled design system for mold using deep semantic understanding and intelligent decision support.

To address the inefficiency and high error rates in traditional methods for handling complex design processes in modern mold design, this study proposes a Knowledge Graph-driven Intelligent Data-enabled Design System for molds. Initially, deep semantic understanding techniques are employed to intelligently parse a large volume of mold design documents and data. Using Bidirectional Encoder Representations from Transformers (BERT) and Random Forest (RF) algorithms, key information and knowledge points are accurately extracted from the design documents, laying a solid foundation for constructing the knowledge graph.