Effects of microRNA-146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting through the NF-κB signalling pathway.

The present study aims to investigate the effects of on the proliferation and apoptosis of human osteoarthritis (OA) chondrocytes by targeting tumour necrosis factor receptor-associated factor 6 (TRAF6) through nuclear factor-κB (NF-κB) signalling pathway. Human normal and OA chondrocytes were selected and divided into the normal group, blank group, negative control (NC) group, mimics group, inhibitors, inhibitor + si-TRAF6 group and si-TRAF6 group. Quantitative real-time PCR (qRT-PCR) was applied to detect the expressions of , mRNA and mRNA.