Publications by authors named "Shou-Mei Zhang"
Article Synopsis
- LAMIN A/C, which is produced by the LMNA gene, plays a crucial role in maintaining the structure of cell nuclei and connecting them to the cytoskeleton.
- Defects in the LMNA gene can lead to conditions like congenital muscular dystrophy and Emery-Dreifuss muscular dystrophy, known as laminopathies.
- Researchers have created a homozygous knockout iPSC line (EHTJUi005-A-3) using CRISPR/Cas9 technology, which serves as a valuable model for studying these diseases.
SUV39H1 is a histone methyltransferase involve numerous biological processes, including of aging, embryo development, tumor growth and mitosis via catalysis of dimethylation and trimethylation of lysine 9 of histone H3. Here we report a human induced pluripotent stem cell line (EHTJUi005-A-1) which is generated from a wildtype human iPSC previously established in our laboratory, and this iPSC has a homozygous knockout of 8 bp in Exon 2 of SUV39H1. This iPSC model provides a valuable resource to study epigenetic regulation in extensive biological processes as mentioned above.
View Article and Find Full Text PDFFamilial Arrhythmogenic Right Ventricular Dysplasia (ARVD) is a primary cardiomyopathy characterized by the abnormality of the right ventricular muscle. ARVD may be life-threatening due to the induction of paroxysmal refractory ventricular tachycardia or supraventricular arrhythmia. A human induced pluripotent stem cell line (EHTJUi004-A) was generated from human umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.
View Article and Find Full Text PDFHypertrophic cardiomyopathy (HCM) is an autosomal dominant heart disease. An induced pluripotent stem cell line (EHTJUi003-A) was generated from umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.L460Wfs (c.
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