[Enzymatic reaction pattern of saponins in Gynostemma pentaphyllum and identification of their transformed products].

The activity of rare saponins is generally better than that of their prototypes. There are significant differences in the proportions and pharmacological effects of rare saponins/prototype saponins in Gynostemma pentaphyllum samples dried with different methods, which may be related to the reaction catalyzed by glucosidase. To explore the pattern of the enzymatic reaction catalyzed by glucosidase during the processing of G.

[Comparison on anti-inflammatory activity of Gynostemma pentaphyllum processed with different methods].

The aim of this study is to investigate the effects of Gynostemma pentaphyllum dried with two different methods(air drying and heating) on inflammation in acute lung injury(ALI) mice in vivo and in vitro. Lipopolysaccharide(LPS) was sprayed into the airway of wild type C57BL/6J male mice to establish the model, and the drug was injected into the tail vein 24 h after modeling. Lung function, lung tissue wet/dry weight(W/D) ratio, the total protein concentration, interleukin 6(IL-6), IL-1β, and tumor necrosis factor-α(TNF-α) in the bronchoalveolar lavage fluid(BALF), and pathological changes of the lung tissue were used to evaluate the effects of different gypenosides on ALI mice.

Chemical constituents from the aerial parts of L. with their NO inhibitory activity.

A new naphthoquinone derivative () together with twenty-three known compounds (-), were isolated from the aerial parts of L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds - were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.

New alkaloids from Pamp.

Sixteen alkaloid compounds were isolated from the dried rhizomes of , including a pair of new enantiomers (/)-7'-ethoxy--p-couma-royltyramine (/) and 14 known compounds (2-14) isolated from this plant for the first time. The structures of new compounds were identified by IR, NMR and MS spectroscopic analysis, and their absolute configurations were determined by comparison of the experimental and calculated ECD data.

L. ameliorates DSS-induced ulcerative colitis in mice through dual inhibition of NLRP3 inflammasome and IL-6/JAK2/STAT3 pathways.

The aerial part of ​ ​L. has been used as an herbal medicine for a long time with various pharmacological activities, including anti-inflammatory, anticancer, and antibacterial activities. The most notable usage of these was that this herbal medicine had good therapeutic effects on diarrhea caused by various factors.

[Comparison of chemical components between aerial and underground parts of Coptis chinensis based on UPLC-Q-TOF-MS~E technology].

The ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS~E) technology was employed to compare the chemical components between the aerial and underground parts of Coptis chinensis samples from different batches. According to the retention time, molecular ion peak, and LC-MS~E fragment information of the reference substances and available literature, we identified a total of 40 components. Thirty-three and 31 compounds were respectively identified in the underground part(taproots) and the aerial part(stems and leaves) of C.

Anthraquinones from the Aerial Parts of with Their NO Inhibitory and Antibacterial Activities.

The present study aimed to identify the composition of the aerial parts of L. A chemical investigation on the EtOAc extracts from the aerial parts of resulted in the isolation of four new anthraquinones, namely Cordifoquinone A-D (-), along with 16 known anthraquinones. Their structures were elucidated on the basis of NMR and HR-ESIMS data.

Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.

A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding -propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds and exhibited significant cytotoxicity of all five cancer cell lines.

[Ecology suitability study of Polygonatum cyrtonema].

Using the 260 geographical distribution records of Polygonatum cyrtonema in China, combined with 53 environmental factors, the maximum entropy modeling(MaxEnt) was used to study the ecological factors affecting the suitability distribution of P. cyrtonema. The ArcGIS software was used to predict the potential distribution of the population of P.

Three new compounds from the flower branch of Blume and anti-microbial activity.

Three new compounds (1-3), including novel tetra--cresol substituted cyclopenta[]naphthalene derivatives, named gastrodinol (1), 2-(4'-hydroxybenzoyl)-3-hydroxyethyl indole (2), 2-(4'-hydroxybenzoyl)-3-(4''-hydroxybenzyl)indole (3) were isolated from the flower branch of , along with five known compounds (4-8). Among them, compound 1 exhibited the most anti-microbial activity against , with the minimum inhibitory concentration of 1 μg ml. This study demonstrated that the novel gastrodinol 1 found in the flower branch of may be responsible for the anti-microbial effect.

Sesquiterpene amino ether and cytotoxic phenols from Dendrobium wardianum Warner.

A new bibenzyl derivative, dendrocandin V (1) and a new sesquiterpene amino ether, wardianumine A (2), together with eleven known compounds, including phenanthrenes (denbinobin (3), 9,10-dihydro-denbinobin (4), mostatin (5), loddigesiinols A (6)), bibenzyls (moscatilin (7), 5-hydroxy-3,4'-dimethoxybibenzyl (8), 3,4-dihydroxy-5,4'-dimethoxy bibenzyl (9), dendrocandin A (10), gigantol (11), dendrocandin U (12)) and an alkaloids (dihydroshihunine, 13) were isolated from the EtOH extraction of stems of Dendrobium wardianum Warner. Isolation of the new compound 2 indicated that N,N-dimethylethanolamine as the key adduction in the synthesis of dendroxine and its analogs in Dendrobium species. The hypothetical biosynthetic pathway of 2 was then postulated.

Seventeen steroids from the pith of Tetrapanax papyriferus.

Two new steroidal ketones (1, 2), together with 10 known steroids (3-12) and five known steroidal saponins (13-17), have been obtained from the pitch of Tetrapanax papyrierus. The structures of 1 and 2 were elucidated as 3β-hydroxystigmast-8, 22-diene-7,11-dione and 3β-hydroxystigmast-8-ene-7,11-dione by IR, HR-ESI-MS, 1D and 2D NMR techniques. Except for 4, 14, 15, 16, 13 compounds reported in this paper were isolated from Tetrapanax papyriferus for the first time.

Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale.

Two new bibenzyl derivatives, dendrocandin T (1) and dendrocandin U (2), together with eight known bibenzyls, were isolated from the stems of Dendrobium officinale. Those compounds were sent for the first time for central nervous system-related bioassay and the results indicated that compounds 3, 4, and 5 have a certain degree of neurite outgrowth-promoting activity, and compounds 1, 2, 6, and 7 also have weak activity. The results indicated that D.

Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes.

Phytochemical investigation of methanol extract from the spikes of Prunella vulgaris L. led to the isolation of two new pentacyclic triterpenoid glycosides Vulgasides I (1) and II (2) along with 13 known compounds (3-15). Their structures were established on the basis of nuclear magnetic resonance (1D and 2D) and mass spectroscopic data analysis.

[Dynamic accumulation of dry substance and active components in root of Peucedanum praeruptorum].

Objective: To study the dynamic accumulation regulation of dry substance and four coumarin constituents in root of Peucedanum praeruptorum, so to provide the basis for optimal harvest time.

Method: Roots of P. praeruptorum were collected periodically.

Qualitative and quantitative analysis of phenolic compounds in the leaves of aquilaria sinensis using liquid chromatography-mass spectrometry.

Introduction: The leaves of Aquilaria sinensis traditionally have been used in China for a century. Phenolic compounds were investigated to be the major active compounds in them.

Objective: To establish a method that will simultaneously determine the phenolic compounds in Aquilaria sinensis leaves and identify their characteristic fragmentation patterns, and to make a comparison of A.

[Studies on the chemical constituents of rhizoma of Coniogramme japonica].

Objective: To study the chemical constituents of Rhizoma of Coniogramme japonica.

Methods: The Rhizome of C. japonica were extracted with ethanol and the chemical constituents were separated by chromatography technique, and their structures were determined by spectral analysis.

[Terpenoid compounds isolated from Ligularia sagitta].

Objective: To study the chemical constituents of radix and rhizome of Ligularia sagitta.

Method: Isolation and purification were carried out on the column chromatography of silica gel and sephadex LH -20. The structures were identified by spectral analysis.

[Medicinal species of genus Polygonum s. lat. distributed in Anhui Province].

Objective: To clarify the resource of medicinal plants of genus Polygonum s. lat. distributed in Anhui Province.

[Species of Ligularia in the northwestern China and their medicinal uses].

Objective: To investigate the species of Ligularia distributed in the northwestern China and their medicinal uses in the local area.

Method: Field investigation, specimen collection, taxonomic study and datum check were adopted.

Result: There are 29 species and 1 varieties of Ligularia distributed in the northwestern China, and 18 species of them had been used as folk medicines with the function of resolving phlegm, relieving cough, clearing heat and toxins.