Publications by authors named "Shou-Cheng Liu"
A novel bifurcation stent coated with bioabsorbable nanofibers that deliver the extended and controlled release of rosuvastatin and paclitaxel was developed. Bioabsorbable bifurcation stents, consisting of a double-slit tubular main body and two spiral branches, were manufactured. Bi-layered poly (lactic-co-glycolic acid) nanofibers that contained rosuvastatin and paclitaxel were used for treating the stents.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM), the most prevalent and malignant form of a primary brain tumour, is resistant to chemotherapy. In this study, we concurrently loaded three chemotherapeutic agents [bis-chloroethylnitrosourea, irinotecan, and cisplatin; BIC] into 50:50 poly[(d,l)-lactide-co-glycolide] (PLGA) nanofibres and an antiangiogenic agent (combretastatin) into 75:25 PLGA nanofibres [BIC and combretastatin (BICC)/PLGA]. The BICC/PLGA nanofibrous membranes were surgically implanted onto the brain surfaces of healthy rats for conducting pharmacodynamic studies and onto C6 glioma-bearing rats for estimating the therapeutic efficacy.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma multiforme has a poor prognosis and is difficult to treat due to its resistance to chemotherapy.
- In a study using C6 glioma-bearing rats, a new biodegradable drug delivery system with poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) was tested, showing significantly higher drug concentrations in the brain compared to blood.
- Results indicated that rats treated with BIC/PLGA nanofibers experienced slower tumor growth, longer survival times, and reduced malignancy of gliomas, making it a promising approach for cancer treatment.