Transduced PTD-BDNF fusion protein protects against beta amyloid peptide-induced learning and memory deficits in mice.

Brain-derived neurotrophic factor (BDNF) promotes the survival and differentiation of hippocampal, cortical, and basal forebrain cholinergic neurons. However, the efficacy of BDNF via peripheral (i.v.

[The effects of lidocaine and chronic stress on neurogenesis in the hippocampal dentate gyrus of adult mice].

Objective: To evaluate the effects of chronic stress and lidocaine administration on the neurogenesis in the hippocampal dentate gyrus of adult mice.

Methods: Twenty-four adult mice were randomly divided into 3 equal groups: control group (Group C), chronic stress group (group S) and lidocaine group (group L). The duration of the experiment was fourteen days.

Inhibition by agmatine on morphine-induced conditioned place preference in rats.

Our previous studies demonstrated the ability of exogenous agmatine to inhibit tolerance to and physical dependence on morphine in mice, rats and monkeys. The present study further evaluated the effect of agmatine on the psychological dependence induced by morphine in conditioned place preference assay. Agmatine (0.