The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism.

Background/aim: Nitric oxide (NO) has antitumor activity against various solid tumor cell types in addition to its vasodilatory effect. In the current study, we investigated the effect and mechanism of the synthetic nitrated form (NO-NAT) of nateglinide, a hypoglycemic agent, on the induction of cell death in human pancreatic cancer cells.

Materials And Methods: NO production was evaluated by measuring nitrite (NO) and nitrate (NO) (NOx).