Publications by authors named "Shotaro Shimokawa"
Purpose: To compare the usefulness of microperimetry and static automated perimetry in patients with retinitis pigmentosa (RP), using macular anatomical metrics as a reference.
Design: Prospective observational study.
Participants: Forty-eight eyes of 48 patients with RP in Kyushu University Hospital who underwent microperimetry-3 (MP-3) and Humphrey Field Analyzer (HFA) 10-2 testing ≥3 times during ≥2 years were included.
Relationships between causative genes and epiretinal membrane formation in Japanese patients with retinitis pigmentosa.
Graefes Arch Clin Exp Ophthalmol
November 2024
Article Synopsis
- - The study aimed to explore the connection between specific genes and macular complications in Japanese patients with retinitis pigmentosa (RP), focusing on three gene types: EYS, USH2A, and RHO.
- - Data from 75 RP patients were analyzed, revealing that those with the EYS gene had a significantly higher incidence of epiretinal membranes (35.7%) compared to the other gene groups, although there were no notable differences in macular edema or holes.
- - The findings suggest that the EYS gene might be linked to an increased risk of developing epiretinal membranes in patients with retinitis pigmentosa.
Retinitis pigmentosa (RP) is an intractable inherited disease that primarily affects the rods through gene mutations followed by secondary cone degeneration. This cone-related dysfunction can lead to impairment of daily life activities, and ultimately blindness in patients with RP. Paradoxically, microglial neuroinflammation contributes to both protection against and progression of RP, but it is unclear which population(s) - tissue-resident microglia and/or peripheral monocyte-derived macrophages (mφ) - are implicated in the progression of the disease.
View Article and Find Full Text PDFPurpose: To investigate the long-term outcomes of cataract surgery in patients with retinitis pigmentosa (RP).
Design: Retrospective, observational study.
Participants: Sixty-four patients with typical RP (22 men, 42 women; average age, 62.
Autoimmune uveitis is a sight-threatening disease induced by pathogenic T cells that recognize retinal antigens; it is observed in disorders including Vogt-Koyanagi-Harada disease (VKH). The roles of specific T cell subsets and their therapeutic potential against autoimmune uveitis are not fully understood. Here we conducted multi-parametric single-cell protein quantification which shows that the frequency of CD161TRAV1-2 mucosal-associated invariant T (MAIT) cells that recognize vitamin B2 metabolite-based antigens is decreased in relapsing VKH patients compared to individuals without active ocular inflammation.
View Article and Find Full Text PDFPurpose: To investigate the rate of the recurrence of cystoid macular edema (CME) secondary to retinitis pigmentosa (RP) after the initiation of topical dorzolamide and the recurrence risk factors.
Methods: We retrospectively analyzed the data of RP patients at Kyushu University Hospital. We included patients who showed a treatment response to 1.
Changes of Serum Inflammatory Molecules and Their Relationships with Visual Function in Retinitis Pigmentosa.
Invest Ophthalmol Vis Sci
September 2020
Purpose: Retinal degeneration involves neuroinflammation, and pro-inflammatory cytokines/chemokines are markedly increased in the eyes of patients with retinitis pigmentosa (RP). In this study, we investigated the changes of serum cytokines/chemokines in RP, and their relationships with visual parameters.
Methods: Forty-five consecutive patients with typical RP aged 20 to -39 years and 28 age-matched and gender-matched controls were included.
Purpose: To investigate the association between aqueous flare and progression of visual field loss using the Humphrey Field Analyzer in patients with retinitis pigmentosa (RP).
Methods: We examined a total of 101 eyes of 101 patients who were diagnosed with typical RP. Sixty-one percent of the patients were female, and the mean age of the total group was 47.
Article Synopsis
- - The study aimed to analyze the relationship between retinal structure and function in patients with retinitis pigmentosa (RP) by comparing microperimetry-3 (MP-3) and optical coherence tomography (OCT) images.
- - Involving 30 RP patients, the researchers measured retinal sensitivity at multiple points in the central retina and explored the correlation between this sensitivity and various retinal thickness parameters.
- - Results indicated that the outer retinal thickness (ORT) had stronger correlations with retinal sensitivity than total retinal thickness (TRT), particularly within the central 6 degrees, suggesting that assessing ORT could be crucial for monitoring RP progression.
Purpose: To investigate the serum changes of antioxidant/oxidant markers and the relationship between these factors and visual function in patients with retinitis pigmentosa (RP).
Methods: Fifty-two RP patients <40 years old and 25 controls were included. Serum samples were analyzed for superoxide dismutase 3 (SOD3) activity, glutathione peroxidase (GPx), potential antioxidant (PAO), and hexanoyl-lysine (HEL).