Effects of Prenatal Exposure to Titanium Dioxide Nanoparticles on DNA Methylation and Gene Expression Profile in the Mouse Brain.

Titanium dioxide nanoparticles (TiO-NP) are important materials used in commercial practice. Reportedly, TiO-NP exposure during pregnancy can affect the development of the central nervous system in mouse offspring; however, the underlying mechanism remains unknown. In the present study, we investigated the impact of prenatal TiO-NP exposure on global DNA methylation and mRNA expression patterns in the brains of neonatal mice.