Rapid G0/1 transition and cell cycle progression in CD8 T cells compared to CD4 T cells following in vitro stimulation.

T-cell population consists of two major subsets, CD4 T cells and CD8 T cells, which can be distinguished by the expression of CD4 or CD8 molecules, respectively. Although they play quite different roles in the immune system, many of their basic cellular processes such as proliferation following stimulation are presumably common. In this study, we have carefully analyzed time-course of G0/1 transition as well as cell cycle progression in the two subsets of quiescent T-cell population following in vitro growth stimulation.