Publications by authors named "Shota Shiina"
The presence of (1 → 3)-β-D-glucan in human plasma is a marker for fungal infections. Currently, the Limulus amebocyte lysate (LAL)-based assay is widely used for the quantification of plasma (1 → 3)-β-D-glucan. However, it has limitations in clinical use, such as an unstable supply of natural resources, complicated manufacturing process, and low-throughput of the reagents.
View Article and Find Full Text PDFDetection of anomalous cells such as cancer cells from normal blood cells has the potential to contribute greatly to cancer diagnosis and therapy. Conventional methods for the detection of cancer cells are usually tedious and cumbersome. Herein, we report on the use of a particle size analyzer for the convenient size-based differentiation of cancer cells from normal cells.
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- c-Met is a receptor that plays a key role in various cellular processes and is found to be overexpressed in different cancers, particularly in breast cancer stem cells (CSCs) where its role is not fully understood.
- Research shows that c-Met expression is significantly higher in Basal-like breast cancer compared to other types, and higher levels are linked to poor prognosis in advanced stages of the disease.
- Using c-Met inhibitors led to decreased cell viability and inhibited tumor-sphere formation in breast cancer cells with high c-Met expression, suggesting that targeting c-Met could be an effective treatment strategy for ALDH1 positive breast CSCs.