Publications by authors named "Shota Sakuma"
EEG and video documentation of benzodiazepine challenge in catatonic stupor: A case report.
Neuropsychopharmacol Rep
June 2024
Introduction: Catatonia, a psychomotor disorder characterized by diverse clinical signs, including stupor and mutism, remains elusive in its causes and a challenge to diagnose. Moreover, it is often underrecognized due to its resemblance to disorders of consciousness. However, when diagnosing catatonia, an antipsychotic medication may exacerbate the condition.
View Article and Find Full Text PDFLupus enteritis is classified into the colon poly-ulcerative type and the small intestine ischemic serositis type. Colon poly-ulcerative lupus enteritis is a disease that is mainly due to mesenteric arteritis. In recent years, 18 F-FDG PET/CT has been frequently used to assess the extent of the disease in patients with systemic vasculitis.
View Article and Find Full Text PDFArticle Synopsis
- - Systemic lupus erythematosus (SLE) is a complex autoimmune disease influenced by genetic and environmental factors, with studies suggesting that mutations in toll-like receptor (TLR) 7 play a role in its onset.
- - Research using SLE-prone NZBWF1 mice revealed that exposure to TLR7 agonist imiquimod worsened lupus nephritis in female mice without increasing autoantibody production, and heightened Th1 cytokine expression was observed in the kidneys.
- - The findings point to a relationship between TLR7 activation, increased IFN-γ expression, and kidney inflammation, suggesting that inhibiting TLR7 and IFN-γ signaling could help manage SLE and prevent