Disappearance of lens epithelial cells detected at the treatment of intraocular lens dislocation 12 months after cataract surgery: A case report.

Purpose: To report a case of disappearance of lens epithelial cells (LECs) detected at the time of treatment for intraocular lens (IOL) dislocation 12 months after cataract surgery.

Observations: A 59-year-old male underwent phacoemulsification with implantation of a posterior chamber acrylic IOL for posterior subcapsular cataract without any complications. Twelve months after cataract surgery, the IOL was dislocated inferiorly from the capsular bag due to rubbing the eye strongly, without capsular deviation.

Prediction of Drug Permeability Using Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.

The strong barrier function of the blood-brain barrier (BBB) protects the central nervous system (CNS) from xenobiotic substances, while the expression of selective transporters controls the transportation of nutrients between the blood and brain. As a result, the delivery of drugs to the CNS and prediction of the ability of specific drugs to penetrate the BBB can be difficult. Although pharmacokinetic analysis using rodents is a commonly used method for predicting human BBB permeability, novel BBB models, such as Transwell models, have been developed recently.

Establishment of a multi-species biofilm model and metatranscriptomic analysis of biofilm and planktonic cell communities.

We collected several biofilm samples from Japanese rivers and established a reproducible multi-species biofilm model that can be analyzed in laboratories. Bacterial abundance at the generic level was highly similar between the planktonic and biofilm communities, whereas comparative metatranscriptomic analysis revealed many upregulated and downregulated genes in the biofilm. Many genes involved in iron-sulfur metabolism, stress response, and cell envelope function were upregulated; biofilm formation is mediated by an iron-dependent signaling mechanism and the signal is relayed to stress-responsive and cell envelope function genes.