Publications by authors named "Shota Kakio"
Article Synopsis
- - Researchers identified a toxic protein assembly called amylospheroids in the brains of Alzheimer's patients, which target the Na,K-ATPase α3 protein and are linked to neurodegeneration.
- - Using an in vitro culture system, the study tracked how amylospheroids form within mature neurons and discovered they primarily accumulate in the trans-Golgi network and are transported through axons.
- - The research found that inhibiting the proteasome increases amylospheroid levels and affects the transport mechanisms, ultimately causing degeneration of neighboring neurons expressing NAKα3, with implications for understanding Alzheimer's disease progression.
Scope: Epidemiological studies have shown that coffee consumption may be associated with a lower risk of developing several neurological disorders, including Alzheimer's disease (AD). Caffeine is a prominent candidate component underlying the preventive effects of coffee; however, the contribution of other constituents is unclear. To clarify this issue, the effect of roasting coffee beans on β-secretase (BACE1) expression in human neuroblastoma SH-SY5Y cells is investigated.
View Article and Find Full Text PDFRecent evidence indicates that hypoxia-inducible vascular endothelial growth factor (VEGF) has neurotrophic and neuroprotective effects on neuronal and glial cells. On the other hand, recent epidemiological studies showed that daily coffee consumption has been associated with a lower risk of several neuronal disorders. Therefore, we investigated the effect of coffee on VEGF expression in human neuroblastoma SH-SY5Y cells.
View Article and Find Full Text PDF