[The effect of Recormon therapy on the quality of life of patients on hemodialysis treatment].

Recormon was given to 34 patients on hemodialysis. The drug's effects on quality of life were judged by the results of clinical, laboratory, experimental and psychological dynamic investigations. The highest effect occurred on the therapy month 6-12.

[The characteristics of the prevention of HB viral infection in hemodialysis units].

Patients and medical personnel of some hemodialysis centres of the north-west region of the Russian Federation were examined for HB-virus infection markers using enzyme immunoassays. Subjects free of HB markers were immunized with ENGEPIX-B vaccine. Immunogenicity of the vaccine was assessed one month and one year after the immunization.

[Risk of infection with hepatitis B and C viruses of medical workers, patients in the hemodialysis ward, and vaccine prophylaxis of hepatitis B infection in these populations].

Markers of hepatitis B (HBsAg, anti-HBs) and C (anti-HCV) were detected in 1990-1992 by enzyme immunoassay in 1581 medical workers, 230 last-year students of medical schools, 269 patients hospitalized at hemoperfusion wards, and 701 blood donors. Hepatitis B markers were detected in medical workers two times more frequently than in donors (HBsAg in 4.7 and 2.

[The course of chronic kidney failure during acetate and bicarbonate hemodialysis].

In patients with chronic renal failure (CRF) given acetate (n = 55) and bicarbonate (n = 45) hemodialysis, the dynamics of the progress of uremia symptoms estimated in marks, the index of the lean body weight, the rate of urea generation, the magnitudes of the dialysis indices according to creatinine and urea, TACur and TADur were studied on a monthly basis for many years. The actual survival rates were calculated. It has been demonstrated that as compared to acetate hemodialysis, in patients on bicarbonate hemodialysis, the progress of uremia symptoms is significantly decelerated (p less than 0.

[Enterosorption in experimental acute kidney failure].

The paper provides the results of 32 experiments on 22 mongrel male dogs with a view to measuring creatinine levels in the lumen of various intestinal segments before and after bilateral nephrectomy and evaluating the effects the enterosorbent brand SKN administered into isolated portions of the intestinal tube on alteration of intraluminal concentrations of creatinine, serum creatinine, and "middle-sized" molecules. Four parts of the intestine were identified: (1) proximal; (2) middle and (3) distal portions of the small intestine, and (4) the large intestine up to the anal sphincter. Two days following bilateral nephrectomy, creatinine levels were increased in the proximal, middle, distal portions of the small bowel and in the large bowel by 18, 11, 5, and 1.

[The effect of acetate and bicarbonate on the tolerance for hemodialysis therapy in chronic kidney failure].

Effects of acetate and bicarbonate dialysates on tolerance to dialysis have been examined in 30 patients with chronic renal failure (CRF). Symptomatic homeostatic impairment (nausea, vomiting, headache) and cardiovascular instability (tachycardia, arrhythmia, dyspnea) were less common (p less than 0.05) in bicarbonate dialysis.

[The effect of acetate and bicarbonate hemodialysis on protein and lipid metabolism in patients with chronic kidney failure].

In 26 patients with chronic renal failure undergoing hemodialysis, use was made of an acetate solution (40 mmol/l) and in 7 patients, of a bicarbonate solution (35 mmol/l). The control group was made up of 20 healthy volunteers. In addition to better tolerance, the bicarbonate dialysis favoured adequate correction of acid-base balance, normalization of hypercholesterolemia, lowering of the rate of protein degradation.

[Vapor-phase gas chromatographic determination of acetate in the blood].

The suggested gas chromatographic vapor phase analysis of the blood for the direct determination of the blood acetate concentration is performed with Soviet equipment and is based on expulsion of acetic acid from its salts and other derivatives after addition of potassium bisulfate and heating of the blood sample at +105 degrees C for an hour in a hermetically sealed flask. To directly measure acetate, a certain vapor phase volume is let into the gas chromatographic evaporator after equal distribution of acetate in the gas and liquid phases is achieved. This method was used to measure the blood acetate levels in the patients with renal insufficiency treated by hemodialysis.

[Bicarbonate hemodialysis in the therapy of chronic kidney failure].

A method of random sampling was applied to 10 CRI patients to analyze the results of 24 hemodialyses with acetate solution for dialysis (35 mmol/l) and 34 hemodialyses with bicarbonate solution for dialysis (35 mmol/l). Significant reduction of complications like headache, nausea, vomiting, tachycardia, dyspnea, extrasystole was observed in bicarbonate dialysis. The concentration of mean molecular uremic toxins was decreased from 5.

[Iron reserves in patients with chronic renal insufficiency].

Hemorrhage values and the amount of iron entering the body with drugs and blood transfusions were determined in 107 patients with the terminal CRF stage. Of them 59 received regular hemodialyses. The level of serum iron and ferritin as well as iron reserves in the body were investigated at the start and end of the study.

Haemoperfusion in the treatment of chronic renal failure in patients on haemodialysis.

The paper is concerned with materials characterizing physicochemical properties of haemosorbents of varying grades. Adsorption of different uraemic toxins was studied. The possibility of microembolization of internal organs and tissues with haemosorbent particles was explored in the course of prolonged treatment with the use of haemosorption.