Publications by authors named "Shona Coutts"
Background: Germ cells arise from a small group of cells that express markers of pluripotency including OCT4. In humans formation of gonadal compartments (cords in testis, nests in ovary) takes place during the 1st trimester (6-8 weeks gestation). In the 2nd trimester germ cells can enter meiotic prophase in females whereas in males this does not occur until puberty.
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- * The study found that T. brucei brucei uses two highly efficient nucleobase transporters, H1 and H4, to absorb allopurinol, which helps prevent the establishment of drug resistance.
- * Long-term exposure to allopurinol did not alter the transport efficiency or uptake mechanisms of these transporters, allowing the parasite to continue thriving on hypoxanthine as a purine source.