Publications by authors named "Sholpan Allamuratova"
Article Synopsis
- The Médecins Sans Frontières project in Uzbekistan has been treating multidrug-resistant tuberculosis (MDR-TB) in Karakalpakstan since 2003, facing high rates of treatment default, especially after scaling up in 2007.
- A retrospective analysis of patients treated between 2003 and 2008 revealed that 20% defaulted after an average of 6 months, with prior default, older age, and higher severity of resistance patterns as key factors.
- The findings highlight the need for enhanced patient and staff support alongside treatment scale-up, as well as the importance of successful initial treatment courses to reduce risks of default and mortality.
Background: A pilot programme to treat multidrug-resistant TB (MDR-TB) was implemented in Karakalpakstan, Uzbekistan in 2003. This region has particularly high levels of MDR-TB, with 13% and 40% among new and previously treated cases, respectively.
Methodology: This study describes the treatment process and outcomes for the first cohort of patients enrolled in the programme, between October 2003 and January 2005.
Background: The DOTS (directly observed treatment short-course) strategy for tuberculosis (TB) control is recommended by the World Health Organization globally. However, there are few studies of long-term TB treatment outcomes from DOTS programs in high-burden settings and particularly settings of high drug resistance. A DOTS program was implemented progressively in Karakalpakstan, Uzbekistan starting in 1998.
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