Publications by authors named "Shokouh Azam Sarrafzadeh"
Article Synopsis
- The study aimed to establish reference ranges for T cell proliferation induced by phytohemagglutinin (PHA-SI) and Bacillus Calmette-Guérin (BCG-SI) to assist in clinical diagnosis.
- Researchers evaluated data from 359 healthy children and 35 patients with cellular immunodeficiency using a colorimetric method to measure cell proliferation and determined reference ranges at the 2.5th and 97.5th percentiles.
- The results showed significant differences in proliferation between healthy controls and patients with immunodeficiency, providing crucial thresholds for diagnosing congenital immunodeficiency diseases.
Purpose: Mendelian susceptibility to mycobacterial disease (MSMD) is a rare primary immunodeficiency, triggered by non-tuberculous mycobacteria or Bacillus Calmette-Guérin (BCG) vaccines and characterized by severe diseases. All known genetic etiologies are inborn errors of IFN-γ-mediated immunity. Here, we report the molecular, cellular, and clinical features of patients from 15 Iranian families with disseminated disease without vaccination (2 patients) or following live BCG vaccination (14 patients).
View Article and Find Full Text PDFMendelian susceptibility to mycobacterial diseases (MSMD) is a rare inheritance syndrome, characterized by a disseminated infection with mycobacterium in children following BCG vaccination at birth. Regarding the vaccination program in Iran, it may consider as a public health problem. The pathogenesis of MSMD is dependent on either insufficient production of IFN-gamma (γ) or inadequate response to it.
View Article and Find Full Text PDFMendelian susceptibility to mycobacterial diseases (MSMD) is a rare inheritance syndrome, characterized by a disseminated infection with mycobacterium in children following BCG vaccination at birth. Regarding the vaccination program in Iran, it may consider as a public health problem. The pathogenesis of MSMD is dependent on either insufficient production of IFN-gamma (γ) or inadequate response to it.
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