[Assessment for the image interpretation of 111In-ibritumomab tiuxetan in the phase II study of 90Y-ibritumomab tiuxetan in patients with relapsed or refractory indolent B-cell lymphoma].

Prior to the 90Y-ibritumomab tiuxetan (Y2B8) therapy, imaging is performed to verify the expected biodistribution of 111In-ibritumomab tiuxetan (In2B8). In order to determine the indication of radioimmunotherapy with Y2B8, the interpretation criteria for altered biodistribution of In2B8 was established. A phase II study of Y2B8 in patients with relapsed or refractory indolent B-cell lymphoma was performed in nine institutions in Japan.

Sentinel lymph node biopsy examination for breast cancer patients with clinically negative axillary lymph nodes after neoadjuvant chemotherapy.

Background: The feasibility and accuracy of sentinel lymph node (SLN) biopsy examination for breast cancer patients with clinically node-negative breast cancer after neoadjuvant chemotherapy (NAC) have been investigated under the administration of a radiocolloid imaging agent injected intradermally over a tumor. In addition, conditions that may affect SLN biopsy detection and false-negative rates with respect to clinical tumor response and clinical nodal status before NAC were analyzed.

Methods: Seventy-seven patients with stages II and III breast cancer previously treated with NAC were enrolled in the study.

Phase I study of radioimmunotherapy with an anti-CD20 murine radioimmunoconjugate ((90)Y-ibritumomab tiuxetan) in relapsed or refractory indolent B-cell lymphoma.

We conducted a phase I study to evaluate the safety and efficacy of radioimmunotherapy with yttrium-90-ibritumomab tiuxetan (Y2B8) in Japanese patients with relapsed or refractory indolent B-cell lymphoma. Indium-111-labeled ibritumomab tiuxetan (In2B8; 3.5 or 5 mCi [129.