Lessons Learned in Practice with Li-Fraumeni Syndrome: LFS-Related Breast Cancer Treatment Strategy and Establishment of a Surveillance System.

We herein present the case of a 33-year-old woman with no family history of metachronous bilateral breast cancer and osteosarcoma, diagnosed with Li-Fraumeni syndrome (LFS), which is a rare autosomal dominant hereditary cancer syndrome associated with a germline variant. She was diagnosed with left distal femoral osteosarcoma at the age of 16, and metachronous bilateral breast cancer at the ages of 29 and 33. When the third cancer was diagnosed, a hereditary tumor syndrome was suspected and the patient was referred to our genetic outpatient clinic.

Nationwide survey (Japan) on spontaneous hemoperitoneum in pregnancy.

Aim: The purpose of this study was to evaluate the current state and clinical characteristics of spontaneous hemoperitoneum in pregnancy (SHiP) in Japan by performing a comprehensive survey.

Methods: We reviewed data on pregnant women who developed SHiP during 2013-2017 (for 5 years), and were admitted to any of the perinatal centers in Japan. The survey assessed maternal background and maternal and neonatal prognosis.

Reliability and validity of the Children's Depression Inventory-Japanese version.

Background: Depression has major negative consequences for individuals and society, and psychological assessment tools for early disease detection are needed. The aim of this study was to investigate the reliability and validity of an updated Japanese version of the Children's Depression Inventory (CDI-J) and set a cut-off score for the detection of depression.

Methods: The participants consisted of 465 children and adolescents aged 7-17 years.

The deposition densities of radiocesium and the air dose rates in undisturbed fields around the Fukushima Dai-ichi nuclear power plant; their temporal changes for five years after the accident.

The deposition densities of radiocesium and the air dose rates were repeatedly measured in a large number of undisturbed fields within the 80 km zone that surrounds the Fukushima Dai-ichi Nuclear Power Plant site between 2011 and 2016, and features of their temporal changes were clarified. The average air dose rate excluding background radiation in this zone decreased to about 20% of the initial value during the period from June 2011 to August 2016, which was essentially a result of the radioactive decay of Cs with a half-life of 2.06 y.

Preeclampsia mediates the association between shorter height and increased risk of preterm delivery.

Background: Maternal short stature has been observed to increase the risk of preterm birth; however, the aetiology behind this phenomenon is unknown. We investigated whether preeclampsia, an obstetric complication that often leads to preterm delivery and is reported to have an inverse association with women's height, mediates this association.

Methods: We studied 218 412 women with no underlying diseases before pregnancy, who delivered singletons from 2005 to 2011 and were included in the Japan Society of Obstetrics and Gynecology perinatal database, which is a national multi-centre-based delivery database among tertiary hospitals.

Association between very advanced maternal age and adverse pregnancy outcomes: a cross sectional Japanese study.

Background: While several studies have demonstrated the increased risk of pregnancy complications for women of advanced age, few studies have focused on women with very advanced age (≥ 45), despite the increasing rate of pregnancy among such women. Furthermore, how such risks of increase in age differ by maternal characteristics are also poorly understood. Thus, we aimed to clarify pregnant outcomes among women with very advanced age and how the effect of age differs by method of conception and parity.

Association of Shorter Height with Increased Risk of Ischaemic Placental Disease.

Background: Although adult height is inversely related with the risk of chronic disease, the association between maternal height and ischaemic placental disease remains unclear.

Methods: We used the national, multicentre Japan Society of Obstetrics and Gynecology perinatal database to assess the risk of preeclampsia, placental abruption, and small for gestational age (SGA) births (birthweight < 10th percentile), which together constitute the syndrome 'ischaemic placental disease', in relation to self-reported height in 218 412 women with no underlying diseases before pregnancy, who delivered singletons in 2005-11. Height was categorised into quartiles as well as considered in linear terms, and its effect on each outcome was estimated using multivariable log binomial regression adjusted for the maternal characteristics.

Standard curves of placental weight and fetal/placental weight ratio in Japanese population: difference according to the delivery mode, fetal sex, or maternal parity.

Objectives: Placental weight (PW) and fetal/placental weight ratio (F/P) have been considered to be useful parameters for understanding the pathophysiology of fetal growth. However, there have been no standard data on PW and F/P in Asian populations. This study was conducted to establish nomograms of PW and F/P in the Japanese population and to clarify characteristics of PW and F/P in this population.

Comparison of 1470 nm Laser and Radial 2ring Fiber with 980 nm Laser and Bare-Tip Fiber in Endovenous Laser Ablation of Saphenous Varicose Veins: A Multicenter, Prospective, Randomized, Non-Blind Study.

Objective: The aim of this study is to compare the clinical efficacy and safety of two laser wavelengths and fiber types in endovenous laser ablation (EVLA) of saphenous varicose veins of the lower limb.

Design: Multi-center prospective randomized non-blind clinical trial.

Patients And Methods: From January 2007 to December 2011, 113 patients (113 limbs) with primary varicose veins were randomized into two groups.

Spatial distributions of radionuclides deposited onto ground soil around the Fukushima Dai-ichi Nuclear Power Plant and their temporal change until December 2012.

Spatial distributions and temporal changes of radioactive fallout released by the Fukushima Dai-ichi Nuclear Power Plant accident have been investigated by two campaigns with three measurement schedules. The inventories (activities per unit area) of the radionuclides deposited onto ground soil were measured using portable gamma-ray spectrometers at nearly 1000 locations (at most) per measurement campaign. Distribution maps of the inventories of (134)Cs, (137)Cs, and (110m)Ag as of March, September, and December 2012 were constructed.

The air dose rate around the Fukushima Dai-ichi Nuclear Power Plant: its spatial characteristics and temporal changes until December 2012.

Distribution maps of air dose rates around the Fukushima Dai-ichi Nuclear Power Plant were constructed using the results of measurement obtained from approximately 6500 locations (at most) per measurement period. The measurements were conducted 1 m above the ground using survey meters in flat and spatially open locations. Spatial distribution and temporal change of the air dose rate in the area were revealed by examining the resultant distribution maps.

Seasonal variation in the prevalence of pregnancy-induced hypertension in Japanese women.

Aim: Whether prevalence rate of pregnancy-induced hypertension (PIH), including gestational hypertension and pre-eclampsia, is lower for summer delivery than for winter delivery remains to be studied in Japanese women.

Methods: The prevalence rate of PIH was retrospectively determined according to month of year at delivery and at conception in 301510 Japanese women who gave birth to singleton infants on or after gestational week 22 between 2005 and 2009.

Results: The overall prevalence of PIH was 4.

Gestational weight gain according to number of fetuses in Japanese women.

Aim: It is unknown whether weekly maternal weight gain differs between Japanese women with singleton, twin, and triplet pregnancies.

Methods: Gestational weight gain defined as net weight gain during pregnancy was analyzed in 135,036 pregnant Japanese women, including 128,838 with singletons, 5573 with twins, and 132 with triplets, who gave birth at ≥22 weeks of gestation between 2007 and 2009. Weekly weight gain was defined as follows: gestational weight gain÷[gestational week (GW) at Delivery-2].

Do uterotonic drugs increase risk of abruptio placentae and eclampsia?

Purpose: To determine whether the use of uterotonics, including oxytocin and prostaglandins, increases the risk of abruptio placentae and eclampsia.

Materials And Methods: A retrospective analysis was conducted among 260,174 Japanese women at term. Demographic characteristics were studied as possible candidates for risk factors of abruptio placentae and eclampsia using multivariate logistic regression analyses.

Prospective risk of abruptio placentae.

Aim: The aim of this study was to better characterize the nature of abruptio placentae (AP) with regard to the timing of onset.

Material And Methods: Prevalence and prospective risk of AP according to gestational week (GW) were determined among 293,899 women who gave birth to singleton infants at and after GW 30. The prospective risk of AP at gestational week N was defined as the number of all women who experienced an AP at ≥GW N divided by the number of all women who gave birth at ≥GW N.

Long-term effects of a universal prevention program for depression in children: a 3-year follow-up study.

Background: The present study evaluates the long-term effects of a universal prevention approach for depression in children. It looks into the 2- and 3-year follow-ups of previously reported postintervention and 1-year outcomes.

Method: One hundred and eighty-nine 3rd grade (8-9 years old) children participated in a five-session, school-based, universal prevention program designed to encourage social skills and peer support.

Clinical features and short-term outcomes of triplet pregnancies in Japan.

Objective: To review clinical features and short-term outcomes of triplet pregnancies among Japanese women.

Methods: A retrospective analysis was carried out among 320 Japanese women with triplet pregnancies (8 monochorionic, 75 dichorionic, and 150 trichorionic triplets; 87 with unknown placental chorionicity) who delivered at 22 gestational weeks or more between January 2005 and December 2008.

Results: Delivery was by cesarean for 315 (98%) women.

Fetal macrosomia in Japanese women.

Aim: It is unknown how to reduce the number of macrosomic neonates among women without hyperglycemia. The aim of this study was to determine clinically useful risk factors for macrosomic neonates among women without hyperglycemia.

Material And Methods: A retrospective observational study was conducted in 117 680 Japanese women without hyperglycemia who gave birth to singleton infants at 37 weeks of gestation or later.

Prospective risk of intrauterine fetal death in monoamniotic twin pregnancies.

This study was conducted to review the overall short-term outcome of monoamniotic twins in Japan and to determine the prospective risk of fetal death so as to adequately counsel parents with monoamniotic twins. Study subjects were 101 women with monoamniotic twins who were registered with the Japan Society of Obstetrics and Gynecology Successive Pregnancy Birth Registry System and who had given birth at ≥22 weeks of gestation during 2002-2009. The gestational week at delivery (mean±SD) was 31.

Prevalence of hyperglycemia during pregnancy according to maternal age and pre-pregnancy body mass index in Japan, 2007-2009.

Objective: To assess the prevalence of hyperglycemia according to maternal age and pre-pregnancy body mass index (BMI) among Japanese women before introduction of the current diagnostic criteria.

Methods: In a retrospective study, data were analyzed from women with singleton pregnancies who were registered with the JSOG Successive Pregnancy Birth Registry System and who gave birth at 22 weeks of gestation or more between January 2007 and December 2009.

Results: Among 138530 women, 3667 (2.

Prospective risk of stillbirth: monochorionic diamniotic twins vs. dichorionic twins.

Aims: To determine reliably the risk of stillbirth among twin pregnancies.

Methods: A data analysis of 3241 and 6581 women with monochorionic diamniotic (MD) and dichorionic (DD) twins, respectively, who gave birth at ≥22 weeks of gestation.

Results: The prospective risk (per 1000 women) of stillbirth, 25.

Changes of radionuclides in the environment in Chiba, Japan, after the Fukushima nuclear power plant accident.

Damage to the Fukushima nuclear power plant caused by the 11 March 2011 earthquake and tsunami off the northeast coast of Japan resulted in the release into the environment of radioactive material. Airborne radioactive material was detected in metropolitan areas near Tokyo, and increases in radiation dose rate were observed at many locations. In this study, repeated measurements with the in situ Ge system were performed in Chiba City, which is about 220 km south of Fukushima.

Risk factors for eclampsia in Japan between 2005 and 2009.

Objective: To determine risk factors for eclampsia among Japanese women with singleton pregnancies.

Methods: A retrospective observational study was carried out among patients with and those without eclampsia who were registered on the Japan Society of Obstetrics and Gynecology registry system and who gave birth to singleton infants at 22 weeks or more between 2005 and 2009. Multivariate logistic regression analyses were performed to determine independent risk factors for eclampsia.

Contribution of twin-to-twin transfusion syndrome to preterm birth among monochorionic biamniotic and bichorionic biamniotic twin pregnancies.

Aims: To determine the contribution of twin-to-twin transfusion syndrome (TTTS) to preterm birth (PTB) at <37 weeks of gestation among Japanese twin pregnancies.

Methods: An observational study using 3241 MC-BA (monochorionic biamniotic) and 6581 BC (bichorionic biamniotic) twin pregnancies. We focused on TTTS, preterm premature rupture of membranes (PPROM), pregnancy-induced hypertension (PIH), and fetal sex as possible causes of PTB.