Publications by authors named "Shoji Kokubo"
A 74-year-old woman underwent colonoscopy for positive fecal occult blood test. A colonoscopy revealed a Type 1 tumor in the rectosigmoid region. The tumor was diagnosed as well-differentiated adenocarcinoma(tub1)by biopsy.
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- * After confirming the recurrence through imaging and biopsy, the patient underwent preoperative chemoradiotherapy (CRT) followed by laparoscopic surgery that successfully removed the cancerous tissue.
- * Post-surgery, he received adjuvant chemotherapy and, after four years of follow-up, showed no signs of cancer recurrence, suggesting that preoperative CRT can be effective for treating locally recurrent rectal cancer cases.
Background: Neuroendocrine cell carcinomas (NEC) of the colon and rectum are uncommon, representing ~ 0.1% of all colorectal carcinomas. They are associated with a much worse prognosis compared to adenocarcinoma of the colon and rectum, as death occurs in approximately half of all patients within 1 year.
View Article and Find Full Text PDFThe ATP-binding cassette subfamily G member 2 (ABCG2) transporter is involved in the development of multidrug resistance in cancer patients. Many inhibitors of ABCG2 have been reported to enhance the chemosensitivity of cancer cells. However, none of these inhibitors are being used clinically.
View Article and Find Full Text PDFA 65-year-old male was diagnosed with rectal cancer invading the urinary bladder, swollen para-aorticlymph nodes, and multiple liver metastases in abdominal CT. After 8 courses of mFOLFOX6 plus panitumumab, the rectal cancer, para-aortic lymph nodes metastasis, and liver metastases decreased significantly in size. Rectal cancer and liver metastases were considered resectable, hence low anterior resection of the rectum was performed.
View Article and Find Full Text PDFIn inflammatory bowel disease, chronic inflammation results in the development of colon cancer known as colitis-associated cancer. This disease is associated with tumor necrosis factor-α (TNF-α) signaling. In addition, intestinal fibrosis is a common clinical complication that is promoted by transforming growth factor β1 (TGF-β).
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- * A case presented involved a 69-year-old man with a 5mm rectal NET that showed regional lymph node metastasis, despite being below the typical surgical threshold.
- * The findings highlight that while size is a key risk factor for metastasis, smaller rectal NETs (≤10mm) can still pose a risk for lymph node involvement, suggesting the need for careful evaluation.