A very rare phenotype of immunoglobulin G4-related disease that was manifested as constrictive pericarditis: a case report.

Background: Constrictive pericarditis (CP) can arise from various causes, including post-operative degeneration, tuberculosis, and sequelae of pericarditis. Immunoglobulin (Ig) G4-related disease is a rare but recognized cause of CP. However, the specific mechanisms underlying these aetiologies and pathologies remain unclear.

Epidemiological trends in head and neck cancer in Nara Prefecture, Japan, from 2000-2021: The impact of the COVID-19 pandemic.

Objective: Epidemiological surveys were conducted in Nara Prefecture, Japan, to determine the prevalence of head and neck cancer in the region since 1986.

Methods: This study examined the dynamics of visits to 18 medical institutions treating head and neck cancer in Nara Prefecture from 2000 to 2021.

Results: A total of 8,605 patients were registered, with 4,788 being male and 3,787 female.

Neonatal acute liver failure cases with echovirus 11 infections, Japan, August to November 2024.

In 2022-23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. In August-November 2024, three neonatal cases of ALF with echovirus 11 (E11) were reported in Tokyo, Japan. All neonates developed irreversible multiple-organ failure and died.

BLV-CoCoMo Dual qPCR Assay Targeting LTR Region for Quantifying Bovine Leukemia Virus: Comparison with Multiplex Real-Time qPCR Assay Targeting Region.

The proviral load (PVL) of the bovine leukemia virus (BLV) is a useful index for estimating disease progression and transmission risk. Real-time quantitative PCR techniques are widely used for PVL quantification. We previously developed a dual-target detection method, the "Liquid Dual-CoCoMo assay", that uses the coordination of common motif (CoCoMo) degenerate primers.

Case Series of Vaccine Hesitancy Encountered at the Pediatric Emergency Department.

Vaccine hesitancy (VH) is a significant concern, although its specific characteristics remain unclear. Moreover, strategies to shift vaccine-hesitant parents' attitudes toward immunization are not yet well-defined. Pediatric emergency department (ED) physicians frequently encounter patients who are inadequately vaccinated due to parental VH; however, it is challenging to allocate sufficient time during ED visits to provide comprehensive vaccination education.

Subsequent bacteremia associated with intravascular catheter colonization with Staphylococcus aureus, Gram-negative rods, and Candida species in children.

Subsequent bacteremia developed in 14 % of patients with positive catheter tip cultures but concurrent negative blood cultures. The occurrence of subsequent bacteremia did not differ significantly by pathogens (Staphylococcus aureus, Gram-negative rods [GNR], and Candida spp.).

Antibody titer trends after SARS-CoV-2 vaccination in patients aged 12-25 years with underlying diseases.

Background: Whereas declines in antibody titers after SARS-CoV-2 vaccination have been reported, most reports are predominantly from adults. Long-term trends in SARS-CoV-2 antibody titers after the first BNT162b2 vaccination series in children and young adults with underlying diseases remain less studied.

Methods: This prospective single-center observational cohort study enrolled patients aged 12-25 years with underlying diseases who received the first BNT162b2 vaccination series.

Associations of physical activity and sedentary time with psychological distress among Japan self-defense forces personnel dispatched overseas: a prospective cohort study.

Objectives: Physical inactivity and sedentary time can worsen mental health; however, their relationship remains elusive, and related evidence among workers with overseas assignments is limited. Therefore, this study aimed to investigate the relationship between changes in physical activity and sedentary time and explored the subsequent risk of psychological distress among Japan Self-Defense Forces personnel.

Methods: This prospective study enrolled male Japan Self-Defense Forces personnel dispatched to the Republic of Djibouti from May 2018 to June 2019.

Design of a potent and selective dual JAK1/TYK2 inhibitor.

Janus kinase (JAK) inhibitors have gathered interest as treatments for several inflammatory and autoimmune diseases. The four first marketed inhibitors target JAK1, with varying selectivity towards other JAK family members, but none inhibit tyrosine kinase-2 (TYK2) at clinically relevant doses. TYK2 is required for the signaling of the interleukin (IL)-12 and IL-23 cytokines, which are key to the polarization of T1 and T17 cells, respectively; two cell subtypes that play major roles in inflammatory diseases.

Bilateral Transankle Intervention as a Critical Determinant of Successful Revascularisation in Complex Peripheral Arterial Disease.

Introduction: Establishing optimal vascular access sites is important for the procedural success of endovascular treatment (EVT) and the patient's comfort afterwards. Among the variety of vascular access sites, the transankle intervention (TAI) has been used more recently; however, there have been no reports of complex lower extremity arterial disease lesions treated with the TAI manoeuvre.

Report: An 82 year old man with chronic limb threatening ischaemia in both lower extremities underwent EVT for bilateral long segment occlusion from the iliac arteries to the superficial femoral artery (SFA).

Association of maternal blood and umbilical cord blood plasma fatty acid levels with the body size at birth of Japanese infants.

Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), mainly obtained from fish, have been implicated in fetal development. Because few studies have examined maternal and umbilical cord blood fatty acid levels and infant body size in Japan with a fish-eating culture, we examined differences in plasma fatty acid levels in pregnant women and infant size at birth. This study is a large birth cohort study of 1476 pairs of Japanese pregnant women and their infants.

Development of Dry and Liquid Duplex Reagent Mix-Based Polymerase Chain Reaction Assays as Novel Tools for the Rapid and Easy Quantification of Bovine Leukemia Virus (BLV) Proviral Loads.

Bovine leukemia virus (BLV) is prevalent worldwide, causing serious problems in the cattle industry. The BLV proviral load (PVL) is a useful index for estimating disease progression and transmission risk. We previously developed a quantitative real-time PCR (qPCR) assay to measure the PVL using the coordination of common motif (CoCoMo) degenerate primers.

Percutaneous Closure Based on Physiological Assessment of an Arteriovenous Fistula in a Patient With Chronic Limb Threatening Ischaemia.

Introduction: An arteriovenous fistula (AVF) is a potential complication of endovascular therapy (EVT). Arteriovenous fistula steal syndrome sometimes leads to severe limb ischaemia; however, assessment of peripheral perfusion in AVF has not yet been established.

Report: A 90 year old woman diagnosed with chronic limb threatening ischaemia underwent EVT.

A latent bleeding complication in ipsilateral common femoral puncture involving delayed diagnosis: a case report.

Background: The trans femoral ipsilateral approach is often adopted for endovascular treatment (EVT) for better steerability of guidewires or better device deliverability. However, contrary to the trans femoral contralateral approach, ipsilateral antegrade puncture sometimes causes peculiar bleeding complications.

Case Presentation: A 76-year-old female underwent EVT for chronic occlusion of the left superficial femoral artery (SFA) via the ipsilateral antegrade approach.

Characteristics of urinary tract infections in children with positive urine culture for Aerococcusurinae.

Urinary tract infections caused by Aerococcus urinae have rarely been reported in children, and the clinical characteristics remain unclear. We reviewed medical records of children whose urine cultures grew A. urinae (≥10 CFU/mL) at a tertiary children's hospital in Tokyo, Japan.

Longitudinal Analysis of One-Carbon Metabolism-Related Metabolites in Maternal and Cord Blood of Japanese Pregnant Women.

One-carbon metabolism (OCM) is a complex and interconnected network that undergoes drastic changes during pregnancy. In this study, we investigated the longitudinal distribution of OCM-related metabolites in maternal and cord blood and explored their relationships. Additionally, we conducted cross-sectional analyses to examine the interrelationships among these metabolites.

Impact of Controlling Nutritional Status Score on Comprehensive Clinical Outcomes in Patients With Chronic Limb-Threatening Ischemia in a Local Area of Super-Aged Society.

Purpose: This study aimed to evaluate the relationship between nutritional status and hospital outcomes in patients with chronic limb-threatening ischemia (CLTI) in a local area of contemporary super-aged society of Japan.

Materials And Methods: We analyzed 131 consecutive patients with 179 lower limb diseases admitted to our hospital for the treatment of CLTI between April 2018 and March 2023. These 131 patients were divided into 3 groups according to hospital outcomes: home discharge (HD), out-of-home discharge (OD), and in-hospital death (ID).