Virologic Response and Safety of Ibuzatrelvir, a Novel SARS-CoV-2 Antiviral, in Adults With COVID-19.

Background: Despite effective vaccines and treatments for COVID-19, clinical burden persists. An unmet need exists for additional effective agents with safety profiles allowing use across a broad population. Ibuzatrelvir is an orally bioavailable SARS-CoV-2 Mpro inhibitor that has demonstrated in vitro antiviral activity and low potential for safety concerns, including drug-drug interactions.

Influence of Narrow-Band Ultra Violet B Phototherapy on Homocysteine Status: A Prospective Study of Patients with Different Cutaneous Disorders.

Artificial ultraviolet (UV) radiation is a mainstay in the treatment of a variety of inflammatory skin disorders. Despite existence from a wealth of studies on the impact of narrow-band UVB (NBUVB) on serum levels of nutrients, clinical data on its effect on serum homocysteine (HC) level, which is thought to be a risk factor for cardiovascular disorders, dementia, and depression, are scarce. To assess serum HC status before and after treatment with at least 30 sessions of NBUVB exposure in patients with various cutaneous disorders.

Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects.

Background: PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharmacodynamics of single (SAD) and multiple ascending doses (MAD) of PF-06650833 immediate-release (IR) and modified-release (MR) oral formulations in healthy adult subjects.

Methods: Study 1 (NCT02224651) was a 96-day, placebo-substitution, SAD study of once-daily (QD) oral PF-06650833 IR 1 to 6000 mg and MR 30 to 300 mg in fasted and fed states.

Effect of Different Water-to-powder Ratios on the Solubility and Microhardness of Calcium-Enriched Mixture Cement.

Introduction: The aim of this study was to evaluate the effect of different water-to-powder (WP) proportions on the microhardness and water solubility of calcium-enriched mixture (CEM) cement.

Methods And Materials: One gram of CEM cement powder was mixed with 0.33 mL, 0.

Effect of Propylene Glycol on the Bond Strength of Two Endodontic Cements.

Introduction: This study evaluated the effect of propylene glycol (PG) on the push-out bond strength of calcium-enriched mixture (CEM) cement compared to mineral trioxide aggregate (MTA).

Methods And Materials: The lumens of two hundred 2±0.2 mm-thick root sections from human extracted teeth were prepared to achieve a diameter of 1.

Effect of Different Water-to-Powder Ratios on the Compressive Strength of Calcium-enriched Mixture Cement.

Introduction: Calcium-enriched Mixture (CEM) cement is an endodontic reparative material available in the form of powder and liquid. The purpose of this study was to determine the effect of different water-to-powder (WP) proportions on the compressive strength (CS) of the cement.

Method Materials And: One gram of CEM cement powder was mixed with either 0.

Compressive Strength of Mineral Trioxide Aggregate and Calcium-enriched Mixture Cement Mixed with Propylene Glycol.

Introduction: The aim of the present study was to evaluate and compare the compressive strength (CS) of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement when mixed with propylene glycol (PG).

Methods And Materials: Twenty four custom-made split molds with 5 holes in each were prepared. Molds were allocated into eight groups (=15 holes) as follows: Groups 1,5: CEM and MTA mixed with PG (100%), Groups 2,6: CEM and MTA mixed with PG (20% )+CEM or MTA liquid (80%) respectively, Groups 3,7: CEM and MTA mixed with PG (50% )+CEM or MTA liquid (50% ) respectively, Groups 4,8: CEM and MTA mixed with CEM or MTA liquid respectively as control groups.

Physical and Chemical Properties of CEM Cement Mixed with Propylene Glycol.

Introduction: the aim of the present study was to evaluate the influence of propylene glycol (PG) on the flowability, microhardness, pH and calcium ion release of calcium-enriched mixture (CEM).

Methods And Materials: CEM cement was mixed with different proportions of PG, as follows: group 1,100% CEM liquid (CL); group 2, 100% PG; group 3, 50% PG and group 4, 20% PG. For assessment of flowability, methodology of ADA Specification No.

Effect of Propylene Glycol on the Sealing Ability of Mineral Trioxide Aggregate and Calcium-Enriched Mixture Cement Apical Barriers.

Introduction: Propylene glycol (PG) improves the handling, physical, and chemical properties of mineral trioxide aggregate (MTA). This study aimed to evaluate the effect of PG on the sealing ability of MTA and calcium-enriched mixture (CEM) apical barriers.

Methods And Materials: A total of 70 extracted human maxillary single-rooted teeth were prepared using ProTaper rotary system.

In Vitro Evaluation of Different Solvents for Retrieval of Mineral Trioxide Aggregate and Calcium-Enriched Mixture.

Introduction: The purpose of this study was to evaluate the effect of different solvents; carbonic acid (H2CO3), hydrochloric acid (HCl), chlorhexidine (CHX) and sodium hypochlorite (NaOCl) on the surface hardness of mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement.

Methods And Materials: Plexiglass molds were prepared and filled with Angelus MTA or CEM cement and then exposed to 2% carbonic acid, 37% hydrochloric acid, 2% chlorhexidine, 5.25% sodium hypochlorite and normal saline at intervals of 1 and 21 days, respectively (n=4).

The Effect of Various Mixing Techniques on the Push-Out Bond Strength of Calcium Enriched Mixture.

Statement Of The Problem: Correct proportioning and mixing are essential to ensure cements attain their optimum physical properties.

Purpose: The aim of this experimental study was to evaluate the influence of various mixing techniques including manual, mechanical mixing, and ultrasonic vibration on push-out bond strength of calcium enriched mixture (CEM).

Materials And Method: Ninety 2-mm-thick dentin disks were prepared from single-rooted human teeth and filled with CEM mixed with manual, trituration, or ultrasonic methods.

Solubility of Two Root-End Filling Materials over Different Time Periods in Synthetic Tissue Fluid: a Comparative Study.

Statement Of The Problem: Insolubility is an important criterion for an ideal root-end filling material to both prevent any microleakage between the root canal and the periradicular space and provide sealing ability.

Purpose: Many recent studies have shown that mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) have acceptable sealing ability. The purpose of this in vitro study was to evaluate the solubility of these root-end filling materials.

The effect of blood contamination on the compressive strength of calcium-enriched mixture.

Statement Of The Problem: In clinical situations, Calcium-Enriched Mixture (CEM) comes into direct contact or even mixes with blood during or after placement.

Purpose: The aim of this study was to evaluate the effect of blood contamination on the compressive strength of CEM.

Materials And Method: Three experimental groups were included in this study.

The effect of chlorhexidine on the push-out bond strength of calcium-enriched mixture cement.

Introduction: The aim of this in vitro study was to evaluate the effect of 2% chlorhexidine (CHX) on the push-out bond strength (BS) of calcium-enriched mixture (CEM) cement.

Methods And Materials: Root-dentin slices from 60 single-rooted human teeth with the lumen diameter of 1.3 mm were used.

Effect of Different pH Values on the Compressive Strength of Calcium-Enriched Mixture Cement.

Introduction: The aim of this study was to evaluate the compressive strength of calcium-enriched mixture (CEM) cement in contact with acidic, neutral and alkaline pH values.

Methods And Materials: The cement was mixed according to the manufacturer's instructions, it was then condensed into fourteen split molds with five 4×6 mm holes. The specimens were randomly divided into 7 groups (n=10) and were then exposed to environments with pH values of 4.

Effect of acidic environment on the push-out bond strength of calcium-enriched mixture cement.

Introduction: This laboratory study was performed to evaluate the effect of different acidic pH values on the push-out bond strength of calcium-enriched mixture (CEM) cement.

Methods And Materials: Forty-eight root dentin slices were obtained from freshly extracted single rooted human teeth and their lumen were instrumented to achieve a diameter of 1.3 mm.

A Comparison between the Antimicrobial Effects of Triple Antibiotic Paste and Calcium Hydroxide Against Entrococcus Faecalis.

Introduction: The purpose of this study was to determine the in vitro antimicrobial ability against Entrococcus (E.) faecalis of triple antibiotic paste and its components compared with calcium hydroxide mixtures.

Materials And Methods: An agar well diffusion assay and MIC method were used to determine the efficacy of the experimental medicaments in removing E.

Myosin translocation in retinal pericytes during free-radical induced apoptosis.

Vascular pathologies induced by ischemia/reperfusion involve the production of reactive oxygen species (ROS) that in part cause tissue injury. The production of ROS that occurs upon reperfusion activates specific second messenger pathways. In diabetic retinopathy there is a characteristic loss of the microvascular pericyte.

Expression and subcellular distribution of filamin isotypes in endothelial cells and pericytes.

Two principal forms of the actin binding protein, filamin, are expressed in mammalian cells: nonmuscle and muscle isotypes (FLN-1 and FLN-2). A protein that copurifies with an alpha-naphthyl acetate hydrolyzing esterase from human omentum microvessel endothelial cells (EC) is isolated by nondenaturing electrophoresis, sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis and electroblotting. The purified protein is subjected to in situ trypsin cleavage, reversed-phase high performance liquid chromatography (HPLC) and automated Edman degradation.

A luminescent europium complex for the sensitive detection of proteins and nucleic acids immobilized on membrane supports.

Certain metal complexes selectively interact with proteins immobilized on solid-phase membrane supports to form brightly colored products. Detecting the absorbance of colorimetric stains is limited by the molar extinction coefficient of the product, however. Development of light-emitting complexes should improve detection sensitivity, but fluorescent labels described to date modify free amino, carboxyl, or sulfhydryl groups often rendering proteins unsuitable for further analysis.

Solid-phase metal chelate assay for quantifying total protein: resistance to chemical interference.

Recently, we developed reversible metal chelate stains that are fully compatible with immunoblotting and protein sequencing. Membrane supports are incubated in Ferrozine/ferrous complex followed by ferrocyanide/ferric complex (double-metal chelate [DMC] stain). Proteins are quantified by computerized densitometry.

Pyrogallol red-molybdate: a reversible, metal chelate stain for detection of proteins immobilized on membrane supports.

Certain metal complexes selectively interact with proteins immobilized on solid-phase membrane supports to form brightly colored products. The metal chelates form protein-dye complexes in the presence of metal ions at acidic pH but are eluted from the proteins by immersing membranes in a solution of basic pH that contains other chelating agents. The reversible nature of the protein staining procedure allows for subsequent biochemical analyses, such as immunoblotting, N-terminal and internal protein sequencing.

Apolipoprotein A-I-containing particles and reverse cholesterol transport in IDDM.

Lipoprotein particles containing apoA-I but not apoA-II are, among high-density lipoproteins, effective protectors against atherosclerosis that act by promoting the efflux of cellular cholesterol and the reverse cholesterol transport process. Because previous studies showed that in vitro nonenzymatic glycosylation of HDL impairs HDL receptor-mediated cholesterol efflux, we isolated Lp A-I from two poorly controlled insulin-dependent diabetic patients and compared the chemical composition and ability to promote cholesterol efflux with the same particles purified from two matched nondiabetic control subjects. No differences in lipid composition or in the ability to promote cholesterol efflux from cultured adipose cells were noted between the two types of Lp A-I preparations.