Publications by authors named "Shohreh Rastegar"
Introduction: A series of studies have evaluated the association between -592A>C and -819T>C polymorphisms in the promoter regions of Interleukin-10 (IL-10) and gastric cancer (GC) risk. However, the results remain inconclusive.
Objective: To better understand the association of the polymorphisms with GC risk, we performed a comprehensive meta-analysis.
Article Synopsis
- A systematic review and meta-analysis assessed the link between the GDF-5 rs143383 polymorphism and knee osteoarthritis (OA) using data from 17 case-control studies with over 17,000 participants.
- The analysis revealed a significant association between the GDF-5 rs143383 polymorphism and the development of knee OA across different ethnicities, control sources, and genotyping methods.
- This polymorphism could serve as a useful risk marker for identifying individuals at risk for radiographic-defined knee OA.
Objective: A comprehensive search on electronic databases was conducted to identify all eligible studies of TNF-α polymorphisms and knee osteoarthritis (OA).
Methods: Eight studies on TNF-α -308 G > A and three on TNF-α -238G > A polymorphism were identified.
Results: Overall, the pooled ORs indicated that neither TNF-α -238G > A nor -238G > A polymorphism was associated with knee OA risk.