Publications by authors named "Shohei Obayashi"
Article Synopsis
- He experienced symptoms like low-grade fever, mild hypoxemia, and febrile neutropenia, requiring treatment with granulocyte colony-stimulating factor (G-CSF).
- After further treatment with hydrocortisone, his condition improved, and his tumors remained stable for 10 months, highlighting potential complications from immune-checkpoint inhibitors during cancer treatment.
Article Synopsis
- - Cryptogenic bilateral fibrosing pleuritis is a rare and poorly understood lung condition with no known treatment options.
- - A 61-year-old man exhibited symptoms such as thickening of the pleura and abnormal fluid in the chest, leading to a diagnosis after a surgical biopsy.
- - Over 16 months, his respiratory health declined quickly, causing issues like high carbon dioxide levels in the blood, necessitating home oxygen and breathing support.
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are common therapeutic agents for EGFR mutation-positive advanced non-small-cell lung cancer. There has been no report of rhabdomyolysis caused by an overdose of EGFR-TKIs. We herein review the existing literature on the subject and report a rare case of rhabdomyolysis due to an overdose of gefitinib, an EGFR-TKI.
View Article and Find Full Text PDFMutations in the gene encoding epidermal growth factor receptor (EGFR) are the most frequent driver mutations in lung adenocarcinoma in Japan. Exon 19 deletion and L858R mutation in exon 21 are the most common EGFR mutations. Uncommon mutations, such as G719X, S768I, and L861Q, and compound mutations, combinations of 2 common or uncommon mutations, have also been reported.
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