The Hippo Signaling Pathway Manipulates Cellular Senescence.

The Hippo pathway, a kinase cascade, coordinates with many intracellular signals and mediates the regulation of the activities of various downstream transcription factors and their coactivators to maintain homeostasis. Therefore, the aberrant activation of the Hippo pathway and its associated molecules imposes significant stress on tissues and cells, leading to cancer, immune disorders, and a number of diseases. Cellular senescence, the mechanism by which cells counteract stress, prevents cells from unnecessary damage and leads to sustained cell cycle arrest.

Analyses of BER-referred noise-to-signal ratio in online measurements of high-baud-rate coherent receivers.

Digital coherent transmission features a very large transmission bandwidth and has played a main role in core optical transmission networks. With the progress of semiconductor technologies, practical coherent transceivers with rates over 100 Gbaud are becoming feasible. With such advances, the transceiver components must have lower power consumption and lower costs, and it becomes important to know how each component contributes to the overall transmission performance.

Ultra-compact coherent receiver with serial interface for pluggable transceiver.

An ultra-compact integrated coherent receiver with a volume of 1.3 cc using a quad-channel transimpedance amplifier (TIA)-IC chip with a serial peripheral interface (SPI) is demonstrated for the first time. The TIA with the SPI and photodiode (PD) bias circuits, a miniature dual polarization optical hybrid, an octal-PD and small optical coupling system enabled the realization of the compact receiver.

Fast optical channel recovery in field demonstration of 100-Gbit/s Ethernet over OTN using real-time DSP.

A field trial of 100-Gbit/s Ethernet over an optical transport network (OTN) is conducted using a real-time digital coherent signal processor. Error free operation with the Q-margin of 3.2 dB is confirmed at a 100 Gbit/s Ethernet analyzer by concatenating a low-density parity-check code with a OTN framer forward error correction, after 80-ch WDM transmission through 6 spans x 70 km of dispersion shifted fiber without inline-dispersion compensation.