Publications by authors named "Shogo Kimura"
Article Synopsis
- * Seventeen otolaryngologists performed Endoscopic Sinus Surgery (ESS) on both 3D-printed models and cadavers, with their performance evaluated using the Objective Structured Assessment of Technical Skills (OSATS) and the time taken for procedures.
- * Results showed no significant differences in surgical scores and performance time between the two groups, indicating that 3D models are a viable and sustainable alternative for assessing surgical skills in ESS.
Article Synopsis
- A new surgical technique was developed to preserve the nasolacrimal duct and inferior turbinate during the treatment of sinonasal inverted papilloma, which involves swinging these structures upward and backward.
- A study on 53 patients showed no recurrences in the maxillary sinus and successful preservation of the nasolacrimal duct in all but one case, indicating the technique's effectiveness.
- The method was found to have low complication rates, with no significant adverse effects reported, making it a safe option for treating inverted papilloma.
Background: Olfactory neuroblastoma (ONB) is a rare malignant tumor arising from the olfactory neuroepithelium. The standard of care for ONB is surgical resection; however, detailed treatment protocols vary by institution. Our treatment protocol consists of endoscopic skull base surgery (ESBS) for endoscopically resectable cases and induction chemotherapy followed by craniotomy combined with ESBS for locally advanced cases, with postoperative radiotherapy performed for all cases.
View Article and Find Full Text PDFA pregnant female domestic longhair cat ~8 mo of age was referred to the Western College of Veterinary Medicine (Saskatoon, Saskatchewan) for a diagnostic evaluation of severe anemia (PCV: 10.8%) after a 2-day period of lethargy. A CBC, serum biochemistry profile, FeLV/FIV testing, and abdominal radiographs were completed and did not determine a cause for the anemia.
View Article and Find Full Text PDFTo secure traceability along supply chains of foodstuffs, the spatiotemporal variability of trace elements' fingerprints (TEF) in fish otoliths provides a powerful tool to determine and discriminate the origin. Spatiotemporal variability of TEF was examined in a commercially important seafood, Japanese eel (), by means of laser ablation-inductively coupled plasma mass spectrometry (LA-ICPMS). Six elemental ratios (Na:Ca, Mg:Ca, P:Ca, K:Ca, Sr:Ca, and Ba:Ca) were determined in the otoliths of specimens originating from four aquaculture farms to examine the spatial variability and from one wild habitat over three years to examine the temporal variation.
View Article and Find Full Text PDFBackground: From the first detection in 2019, SARS-CoV-2 infections have spread rapidly worldwide and have been proven to cause an urgent and important health problem. SARS-CoV-2 cell entry depends on two proteins present on the surface of host cells, angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). The nasal cavity is thought to be one of the initial sites of infection and a possible reservoir for dissemination within and between individuals.
View Article and Find Full Text PDFArticle Synopsis
- The study compares the effectiveness of open septorhinoplasty (OSR) versus septoplasty with a Killian incision (KI) in correcting caudal deviation of the nasal septum, using CT scans for measurement.
- Results showed that OSR significantly improved both nasal airway resistance and patient-reported nasal obstruction symptoms, while KI did not.
- The findings suggest that OSR is a more effective method for correcting caudal deviation than KI, highlighting the importance of evaluating nasal septum deviation through objective metrics like the anterior-posterior position.
Zinc is an essential micronutrient in human body and a vital cofactor for the function of numerous proteins encoded by the human genome. Zinc has a critical role in maintaining many biochemical and physiological processes at the molecular, cellular, and multiple organ and systemic levels. The alteration of zinc homeostasis causes dysfunction of many organs and systems.
View Article and Find Full Text PDFBackground: Although the close relationship between the upper and lower airways has been highlighted previously, little is known about the association between lung function and the recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP). This study aimed to evaluate the factors associated with pulmonary function that affect CRSwNP recurrence after surgery.
Methods: We performed a series of routine pulmonary function tests for general anesthesia prior to CRSwNP surgery.
Article Synopsis
- The study aimed to evaluate the effectiveness of endoscopic surgery for patients with sinonasal squamous cell carcinoma (SNSCC), which usually requires a more invasive open surgical approach due to its aggressive nature.
- Researchers analyzed 15 patients who underwent endoscopic surgery without any prior open methods, focusing on cases where tumors could be fully visualized and removed.
- Results showed a 5-year overall survival rate of 72.4% and highlighted that patients with negative surgical margins had significantly better outcomes compared to those with positive margins, suggesting that endoscopic surgery can be a viable option in specific cases of SNSCC.
Article Synopsis
- Nivolumab has shown better outcomes in treating advanced gastric cancer (AGC) compared to best supportive care, especially in patients who have undergone at least two prior treatments.
- A study assessed the efficacy and safety of nivolumab in AGC patients, revealing that those with poor performance status (PS) had significantly shorter overall survival and lower disease control rates compared to those with better PS.
- The findings suggest that while nivolumab is a possible treatment option for AGC patients with poor PS, it may not be effective enough as a third or later-line therapy due to insufficient survival benefits.
Objectives: There is no standard chemotherapy for advanced pancreatic cancer (APC) after gemcitabine plus nab-paclitaxel (GP) failure. The aim of this study was to evaluate the efficacy and safety of FOLFIRINOX (5-Fluorouracil, leucovorin, irinotecan, and oxaliplatin) (5-Fluorouracil, leucovorin, irinotecan, and oxaliplatin) (FFX) and modified FFX (mFFX) for APC patients after GP failure.
Methods: We retrospectively evaluated the efficacy and safety of FFX in APC patients who were refractory or intolerant of GP.
Objectives: Because reference intervals (RIs) for biochemistry analytes matched to the Russian population are not well defined, we joined the global study on reference values (RVs) coordinated by the IFCC Committee on Reference Intervals and Decision Limits (C-RIDL).
Methods: According to the C-RIDL harmonized protocol, 793 healthy volunteers were recruited in Saint-Petersburg, Moscow, and Yekaterinburg. Serum samples were tested for 34 biochemistry analytes.
Article Synopsis
- Takotsubo cardiomyopathy (TCM), also known as stress-induced cardiomyopathy, is a rare condition that can occur following an infusion reaction.
- In this case, a 65-year-old man with gastric cancer experienced an infusion reaction after receiving trastuzumab monotherapy, leading to significant heart problems.
- His diagnosis was confirmed through various heart tests that showed abnormal heart activity and elevated biomarkers, marking this as the first documented instance of TCM related to an infusion reaction.
Article Synopsis
- - A nationwide study in Turkey aimed to establish reference intervals (RIs) for blood parameters by collecting samples from 12 labs and analyzing them within 2 hours for accurate results.
- - Results showed that different blood analyzers produced varying results, leading to the need for manufacturer-specific RIs for certain parameters like basophils and MCHC.
- - Significant regional differences in blood parameters were found across Turkey, likely linked to nutritional and environmental factors, highlighting the importance of local variations in establishing health benchmarks.
Objectives: The intent of this study, based on a global multicenter study of reference values (RVs) for serum analytes was to explore biological sources of variation (SVs) of the RVs among 12 countries around the world.
Methods: As described in the first part of this paper, RVs of 50 major serum analytes from 13,396 healthy individuals living in 12 countries were obtained. Analyzed in this study were 23 clinical chemistry analytes and 8 analytes measured by immunoturbidimetry.
Article Synopsis
- The IFCC Committee conducted a global study to create harmonized reference intervals (RIs) for medical testing, examining variations in reference values (RVs) across different countries.
- The study involved 12 countries and over 13,000 healthy adults, measuring 50 different analytes to determine RIs through multiple statistical methods.
- Results revealed significant differences in RVs among countries, particularly influenced by factors like nutritional status and BMI, suggesting a need for further validation to ensure accurate medical assessments.
Purpose: We examined the effect of the angiotensin II receptor antagonist (ARB), irbesartan (Irb), on urinary markers in hypertensive patients.
Subjects And Methods: We evaluated 87 patients in a 12-month prospective study: Group 1) 33 patients who were newly administered Irb (100 mg); Group 2) 33 patients who were switched to Irb ; and Group 3) 21 patients who did not undergo change to pre-existing Irb administration. Height, weight, systolic and diastolic blood pressure, clinical parameters, urine protein : creatinine ratio (UPC), and urinary markers (liver-type fatty acid binding protein (L-FABP), N-acetyl-β-d-glucosaminidase, α1-microglobulin, and β2-microglobulin) were measured at the baseline and at 12, 24, and 48 weeks.
[Introduction of Percutaneous Dilational Tracheotomy in Otolaryngology Residency Training].
Nihon Jibiinkoka Gakkai Kaiho
December 2015
In 2009, we introduced percutaneous dilational tracheotomy (PDT) in otolaryngology residency training. PDT was performed in 21 cases and five residents had an opportunity to learn PDT. No major complications occurred.
View Article and Find Full Text PDFArticle Synopsis
- Interstitial fibrosis contributes significantly to chronic allograft injury, potentially leading to organ loss in kidney transplants.
- A study of 36 renal transplant cases over various time points revealed that circulating fibrocytes (CF) and α-smooth muscle actin (SMA)-positive cells are involved in the renal allograft injury process, particularly in the early post-transplant period.
- Although CF levels initially increased within 2-4 weeks post-transplant, they decreased by one year, while α-SMA-positive areas increased, suggesting a role of myofibroblasts in promoting fibrosis over time.
Article Synopsis
- A 40-year-old woman underwent her second kidney transplant after previous surgeries and developed antibody-mediated rejection (AMR) alongside a BK virus infection.
- She had a history of kidney problems starting from the age of 17, needing hemodialysis and first transplant at 18, which led to chronic rejection two and a half years later.
- Treatment for her AMR involved multiple immunosuppressants, plasma exchange, and steroid therapy, ultimately leading to improved kidney function, and she was discharged with a decreased serum creatinine level.