Publications by authors named "Shogo Iseki"
Article Synopsis
- HIF-1 signaling is regulated by oxygen levels and is heightened in low-oxygen (hypoxic) conditions, leading to increased expression of genes that help with cell survival, growth, and the formation of new blood vessels (angiogenesis).
- Compounds that can activate HIF-1, such as the microbial metabolite teleocidin B-4 and other PKC activators, show promise for treating ischemic diseases.
- These PKC activators work by promoting the accumulation of HIF-1α protein through specific cellular pathways, indicating they could be useful therapeutic agents without the cancer-promoting effects seen in some other compounds.
