Preclinical Development of a vWF Aptamer to Limit Thrombosis and Engender Arterial Recanalization of Occluded Vessels.

Endothelial surface and circulating glycoprotein von Willebrand factor (vWF) regulates platelet adhesion and is associated with thrombotic diseases, including ischemic stroke, myocardial infarction, and peripheral vascular disease. Thrombosis, as manifested in these diseases, is the leading cause of disability and death in the western world. Current parenteral antithrombotic and thrombolytic agents used to treat these conditions are limited by a short therapeutic window, irreversibility, and major risk of hemorrhage.

Cardiorespiratory Fitness of University Volleyball Players and Sedentary Young People in Marathwada Region of Maharashtra Province in India.

Background: Volleyball is considered a physically demanding athletic sport; characterized by rapid acceleration, deceleration, and sudden changes of direction. It has been highlighted that aerobic capacity (VO2 max) which indicates cardiorespiratory fitness has a significant effect on the performance of athletes and is an important element of success in sports.

Aim And Objective: The objective of this study was to compare aerobic capacity of university volleyball players from the region with that of matched sedentary controls.

Assessment of Pesticide Contamination in Ground Water from Intensive Agricultural Sites, Using Gas Chromatography-Mass Spectrometry.

A methodology proposed by US EPA (8081-B) is adopted with some modifications for low level pesticide residue analysis in ground water samples. The method is based on liquid-liquid extraction and gas chromatography with electron capture detector (GC-ECD), and confirmed by gas chromatography-mass spectrometry (GC-MS). For this study, different classes of pesticides were selected, both recent and old persistent molecules, namely organochlorine and pyrethroid insecticides.

Analysis on structural, SHG efficiency, optical and mechanical properties of KDP single crystals influenced by Glycine doping.

Good quality single crystals of potassium dihydrogen orthophosphate (KDP) were grown with different doping concentration of Glycine by conventional solution technique in aqueous solution. X-ray diffraction study has been carried out in order to see the effect of dopant on the structural parameters of KDP. There is no additional phase was observed which was further confirmed by Raman spectroscopic analysis.

Growth responses and metal accumulation capabilities of woody plants during the phytoremediation of tannery sludge.

Five woody plants species (i.e. Terminalia arjuna, Prosopis juliflora, Populus alba, Eucalyptus tereticornis and Dendrocalamus strictus) were selected for phytoremediation and grow on tannery sludge dumps of Common Effluent Treatment Plant (CETP), Unnao (Uttar Pradesh), India.

Efficient synthesis of thymidine boranophosphoramidates conjugated with amino acids.

An efficient synthesis of a thymidine boranophosphoramidate prodrug was accomplished using a phosphoramidite approach in high yield. This new class of compounds is designed to have improved antiviral and anticancer advantages conferred by combining the boranophosphate and normal nucleoside amino acid phosphoramidate. Compounds were characterized by MS and 31P NMR.

Synthesis of 5-ethynyl-2'-deoxyuridine-5'-boranomono phosphate as a potential thymidylate synthase inhibitor.

The 5-ethynyl-2'-deoxyuridine nucleoside and the 5'-boranomonophosphate nucleotide were synthesized as analogs of 5-fluoro-2'-deoxyuridine monophosphate (5-FdUMP), a widely used mechanism-based inhibitor of thymidylate synthase. Synthesis was carried out from protected 5-iodo-2'-deoxyuridine and trimethylsilylacetylene by Sonogashira palladium-catalyzed cross coupling reaction followed by selective phosphorylation and finally boronation.

Plasmodium lactate dehydrogenase assay to detect malarial parasites.

Background: Microscopic examination of blood smears remains the gold standard for the diagnosis of malaria. However, it is labour-intensive and requires skilled operators. Immunochromatographic dipstick assays provide a potential alternative.

Unusual presentation of enteric fever: three cases of splenic and liver abscesses due to Salmonella typhi and Salmonella paratyphi A.

Enteric fever is a multisystem disorder caused mainly by Salmonella typhi and Salmonella paratyphi A. It continues to be a major public health problem, especially in developing countries. Unusual presentations of Salmonellosis are rare.

Fatal case of Salmonella enterica subsp. arizonae gastroenteritis in an infant with microcephaly.

Salmonella enterica subsp. arizonae is a common gut inhabitant of reptiles, with snakes as the most common reservoir. Though human cases due to this organism are exceedingly rare, it may infect young infants and immunocompromised individuals with a history of intimate associations with reptiles.

Solid-Phase Synthesis and Photophysical Properties of DNA Labeled at the Nucleobase with Ru(bpy)(2)(4-m-4'-pa-bpy)(2+).

A facile procedure for incorporating a Ru(diimine)(3)(2+) complex at the nucleobase in an oligonucleotide is reported that combines the advantages of Pd(0) cross-coupling and solid-phase DNA chemistries. These ruthenium-modified oligonucleotides form stable duplexes, and the favorable photophysical properties associated with the Ru(diimine)(3)(2+) complex are retained after site-specific covalent attachment.