Potassium-lowering effects of sodium zirconium cyclosilicate in the early post-transplant period.

Problem: Hyperkalemia is a serious condition among intra-abdominal transplant recipients, and the safety and efficacy of sodium zirconium cyclosilicate (SZC) for its management during the early post-transplant period are not well-established.

Methods: Adults who received at least one 10-g dose of SZC within 14 days after an intra-abdominal transplant between January 2020 and July 2022 were included in our study. The primary outcome was the change in potassium (K+) levels following the first SZC dose.

Metabolomics and cytokine profiling of mesenchymal stromal cells identify markers predictive of T-cell suppression.

Background Aims: Mesenchymal stromal cells (MSCs) have shown great promise in the field of regenerative medicine, as many studies have shown that MSCs possess immunomodulatory function. Despite this promise, no MSC therapies have been licensed by the Food and Drug Administration. This lack of successful clinical translation is due in part to MSC heterogeneity and a lack of critical quality attributes.

Endothelial cells and cathepsins: Biochemical and biomechanical regulation.

Cathepsins are mechanosensitive proteases that are regulated not only by biochemical factors, but are also responsive to biomechanical forces in the cardiovascular system that regulate their expression and activity to participate in cardiovascular tissue remodeling. Their elastinolytic and collagenolytic activity have been implicated in atherosclerosis, abdominal aortic aneurysms, and in heart valve disease, all of which are lined by endothelial cells that are the mechanosensitive monolayer of cells that sense and respond to fluid shear stress as the blood flows across the surfaces of the arteries and valve leaflets. Inflammatory cytokine signaling is integrated with biomechanical signaling pathways by the endothelial cells to transcribe, translate, and activate either the cysteine cathepsins to remodel the tissue or to express their inhibitors to maintain healthy cardiovascular tissue structure.

Evaluation of pearl millet and field peas plus triticale silages for midlactation dairy cows.

A mixture of field peas and triticale was planted in spring, harvested as silage, and followed by a double crop of pearl millet, which also was harvested as silage. Eighteen Holstein cows were fed diets based on pea with triticale, pearl millet, or alfalfa plus corn silages. Dry matter digestibility of the pea with triticale diet was higher than for control (71.

Comparison of two methods for enumeration of anaerobe numbers on forages and evaluation of ethylene oxide treatment for forage sterilization.

Experiments were conducted to (i) compare most-probable-number (MPN) procedures with roll tube procedures for enumeration of forage anaerobic bacteria and (ii) evaluate the efficacy of using ethylene oxide to sterilize wet herbage. Alfalfa, corn, and alfalfa-orchardgrass silages and alfalfa and orchardgrass herbages were analyzed for total anaerobic bacteria (medium pH, 6.8) and acid-tolerant anaerobic bacteria (medium pH, 4.

Digestibility of nitrogen in heat-damaged alfalfa.

In order to partition indigestible N in heat-damaged forages into its various chemical fractions, alfalfa (41.1% dry matter), stored in an upright stave silo, was not sealed, and heating was promoted. Silage was labeled as unheated silage (temperature below 20 degrees C); 35 degrees C silage (temperature near 35 degrees C, 5220 degrees C d); and 60 degrees C silage (temperature near 60 degrees C, 10,800 degrees C d).

Etiology of ammoniated hay toxicosis.

Some animals consuming hay treated with anhydrous ammonia have developed neurological signs including hyperexcitability, circling and convulsions. A series of experiments was conducted to identify tentatively the toxin and determine its mode of action. Three out of four sheep fed ammoniated orchardgrass hay (approximately 4% ammonia on a dry basis) developed convulsions.

Relationship between magnesium intake and fecal magnesium excretion of ruminants.

Twenty-four wethers were fed fresh cut orchardgrass, fertilized so that the magnesium concentration in the forage varied, and six lactating dairy cows were fed a 60% concentrate diet supplemented so that the magnesium concentration in the diet varied. This was to evaluate relationships between intake of magnesium and fecal excretion of magnesium in ruminants. Linear and logarithmic equations were evaluated for sheep and dairy cows.

Effects of propionic acid added to supplemental corn on utilization of complete ensiled diets by lactating dairy cows.

Two bottom unloading silos were filled with alternate loads of alfalfa (Medicago sativa L.) and ground shelled corn grain mix (1:5, grain:forage, wet basis) to determine effects of propionic acid added to supplemental corn on performance of lactating dairy cow consuming a complete ensiled diet. One silo received grain mix containing 1% propionic acid.