Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers: A Phase 3 Randomized Clinical Trial.

Importance: Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs).

Objective: To study the efficacy of topical esmolol for healing of uninfected DFUs.

Design, Setting, And Participants: A randomized, double-blind, multicenter, phase 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India.

Clinical-epidemiological Profile of Coronavirus Disease 19 Associated Mucomycosis (CAM) and Relation with Zinc and Iron Levels.

Introduction: Coronavirus disease associated mucormycosis (CAM), perturbed a lot by reaching to epidemic proportions particularly during the second wave of the pandemic.

Material And Methods: This was a retrospective, observational study of patients with COVID-19-associated mucomycosis admitted in April-May 2021 at a tertiary care teaching hospital. Demographic profile, clinical and laboratory parameters were recorded Multidisciplinary treatment including antifungals and surgical interventions were noted.

Follow-up Study of Pulmonary Function, Exercise Capacity and Radiological Changes after Recovery from Moderate to Severe COVID Pneumonia without Mechanical Ventilation.

Background: The long-term effects of COVID on the lungs remain unclear, but, given the extent of the pandemic, it has the potential to become a significant chronic global health problem .Aim of our study was to ascertain the proportion of patients with moderate to severe pneumonia but without mechanical ventilation who have compromised exercise capacity, pulmonary function test and presence of radiological abnormalities and to study any correlation between clinical features with radiological abnormalities.

Methods: In a hospital-based study, COVID-19 patients with moderate and severe pneumonia were followed 3 months after discharge and assessed with chest computed tomography (CT) imaging, 6 minute walk test and pulmonary function tests.

Clinical profile of malaria at a tertiary care teaching hospital in North India.

Introduction: Despite recent reductions in the overall malaria case incidence, malaria remains an important public health issue. There has been a change in clinical and epidemiological profile of malaria in our country and vivax malaria known to be benign has been reported to cause severe complications. Therefore, the present study was conducted to delineate the clinical profile of malaria, proportion of severity, spectrum of complications, and presence of comorbidities among adult patients admitted at a tertiary health-care center in North India.

Schwannoma in anterior mediastinum with massive pericardial effusion.

Schwannoma is a benign nerve sheath neoplasm of schwann cell origin. Mediastinum is the second most common site of schwannoma with majority originating in the posterior medistinum. Mediastinal schwannoma is slow growing and mostly asymptomatic in presentation.