Publications by authors named "Sho Uemura"

Article Synopsis
  • Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that is hard to diagnose and has a poor outlook, highlighting the need for better biomarkers for diagnosis and prognosis.
  • A study identified extracellular vesicles (EVs) marked by O-glycan-binding lectins (ACA) as a promising diagnostic tool for PDAC, using a system called ExoCounter.
  • Analysis of serum samples from 44 patients showed that an increase in ACA-positive EVs post-surgery was linked to shorter overall survival and recurrence-free survival, making it a potential independent predictor of poor prognosis in PDAC.
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Background: Postoperative pancreatic fistula (POPF) is a major complication of distal pancreatectomy (DP). Although the visceral fat area (VFA) is a risk factor for POPF in DP, its measurement is complicated. This study aimed to identify a simple marker as a predictive indicator of POPF.

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Millicharged particles appear in several extensions of the standard model, but have not yet been detected. These hypothetical particles could be produced by an intense proton beam striking a fixed target. We use data collected in 2020 by the SENSEI experiment in the MINOS cavern at the Fermi National Accelerator Laboratory to search for ultrarelativistic millicharged particles produced in collisions of protons in the NuMI beam with a fixed graphite target.

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Article Synopsis
  • Alterations in the KRAS, CDKN2A, TP53, and SMAD4 genes are significant factors in the development of pancreatic cancer, but how they affect patient outcomes was not fully understood in larger studies.
  • Researchers examined a diverse group of 1,146 pancreatic cancer patients to identify relationships between specific gene alterations and patient survival rates using advanced statistical methods.
  • Findings revealed that loss of SMAD4 expression and an increased number of altered genes correlated with poorer disease-free survival and overall survival rates, along with a higher likelihood of liver metastasis rather than local recurrence.
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KRAS mutation is a major driver of pancreatic carcinogenesis and will likely be a therapeutic target. Due to lack of sensitive assays for clinical samples of pancreatic cancer with low cellularity, KRAS mutations and their prognostic association have not been fully examined in large populations. In a multi-institutional cohort of 1162 pancreatic cancer patients with formalin-fixed paraffin-embedded tumor samples, we undertook droplet digital PCR (ddPCR) for KRAS codons 12/13/61.

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We introduce a Xilinx RF System-on-Chip (RFSoC)-based qubit controller (called the Quantum Instrumentation Control Kit, or QICK for short), which supports the direct synthesis of control pulses with carrier frequencies of up to 6 GHz. The QICK can control multiple qubits or other quantum devices. The QICK consists of a digital board hosting an RFSoC field-programmable gate array, custom firmware, and software and an optional companion custom-designed analog front-end board.

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Image sensors with nondestructive charge readout provide single-photon or single-electron sensitivity, but at the cost of long readout times. We present a smart readout technique to allow the use of these sensors in visible light and other applications that require faster readout times. The method optimizes the readout noise and time by changing the number of times pixels are read out either statically, by defining an arbitrary number of regions of interest in the array, or dynamically, depending on the charge or energy of interest in the pixel.

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We present the first direct-detection search for sub-GeV dark matter using a new ∼2-gram high-resistivity Skipper CCD from a dedicated fabrication batch that was optimized for dark matter searches. Using 24 days of data acquired in the MINOS cavern at the Fermi National Accelerator Laboratory, we measure the lowest rates in silicon detectors of events containing one, two, three, or four electrons, and achieve world-leading sensitivity for a large range of sub-GeV dark matter masses. Data taken with different thicknesses of the detector shield suggest a correlation between the rate of high-energy tracks and the rate of single-electron events previously classified as "dark current.

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