The complex interplay between cognitive reserve, age of diagnosis and cognitive decline in Alzheimer's disease: a retrospective study.

Objective: The present study examined the cognitive reserve (CR) theory at late stages of Alzheimer's disease (AD). The objective is to replicate previous studies and examine the complex role of education and family size as indicators of CR.

Participants And Methods: This is a retrospective study included 642 patients diagnosed with AD after age 65, categorized into low education (LE, ≤ 8 years,  = 141) and medium-high education (MHE, ≥ 9 years,  = 442) groups.

Characterization of Meningitis and Meningoencephalitis in the Israeli Defense Forces From 2004 to 2015: A Population-Based Study.

Background: Meningitis and meningoencephalitis (MME) are potential medical emergencies. Mandatory reporting of all MME cases in the Israel Defense Force (IDF) allows accurate characterization of MME incidence and course. In the present study, we described the epidemiology of MME in soldiers.

A unified brain system of orientation and its disruption in Alzheimer's disease.

Objective: To investigate whether a unified brain system manages one's orientation to different places, events and people in one's environment, and test the hypothesis that failure of this system (disorientation) is an early sign of Alzheimer's disease (AD).

Methods: A total of 46 participants (patients along the AD continuum and cognitively normal control subjects) were tested in a personalized, ecologically valid task of orientation relating to the participant's own world in space, time and person under high-density electroencephalography. As a first step, we used evoked potential mapping to search for brain topography correlated with participants' performance in orientating themselves to different places (space), events (time) and people (person) (Experiment 1).

Mental-orientation: A new approach to assessing patients across the Alzheimer's disease spectrum.

Objective: This study aims to assess the role of mental-orientation in the diagnosis of mild cognitive impairment and Alzheimer's disease using a novel task.

Method: A behavioral study (Experiment 1) compared the mental-orientation task to standard neuropsychological tests in patients across the Alzheimer's disease spectrum. A functional MRI study (Experiment 2) in young adults compared activations evoked by the mental-orientation and standard-orientation tasks as well as their overlap with brain regions susceptible to Alzheimer's disease pathology.

Intraarterial multi-modal reperfusion therapy for acute ischemic stroke: a10 year single-center experience.

Background: Only 0.5% of stroke patients in Israel are treated with endovascular multi-modal reperfusion therapy (MMRT) each year.

Objectives: To assess our experience with MMRT over the last decade.