[Dynamics of prostate-specific antigen concentration--growth kinetics of prostate cancer?].

Current research confirms that the prostate-specific antigen (PSA) is not just a protein required for liquefaction of the ejaculate but it plays biological role in the development of prostate cancer. Assessment of the PSA dynamics offers good opportunities for understanding the kinetics of growth of prostate tumors. The most frequently it is performed calculation of PSA doubling time (PSADT), a parameter that requires a logarithmic analysis and takes into account the exponential nature of tumor growth.

[First experience of Ho:YAG laser urethrotomy in the treatment of strictures in patients with prostate cancer].

Strictures of vesicourethral anastomosis (VUA), urethral strictures, and bladder neck obliteration are frequent complications occurring after treatment for prostate cancer and dramatically reducing the quality of life of the patients. To date, there is no single standard treatment of urethral strictures. One of the promising methods is laser optical urethrotomy using a solid-state Ho:YAG- laser.

[First experience of using positron emission tomography with 11C-choline in prostate cancer (PC)].

Introduction into clinical practice of combined positron emission technology and computer tomography (PET/CT) allows in one study to identify structural and functional abnormalities. The study involves 32 patients who underwent PET/CT with "C-choline, including 5 patients with prostate cancer (PC), 3--with chronic prostatitis and 24--with biochemical PC recurrence. PET/CT with 11C-choline has a high diagnostic efficacy in detection of local recurrence and PC metastases in patients with biochemical PC recurrence.

[Characteristics of surgical approach using for patients with renal cell carcinoma, complicated by postcava tumor thrombosis].

The postcava tumor thrombosis had about 1/3 of patients with renal cell carcinoma at the initial examination. Reconstructive interventions were performed on the postcava for 38 patients (24 men, 14 women). The postcava thrombectomy was applied in 15 patients.

[The possibilities of surgical and combined treatment of patients with locally-disseminated renal cell carcinoma].

A comparative analysis of surgical and combined treatment of renal carcinoma in 84 patients has shown that preoperative embolization of the renal arteries failed to reduce blood loss and duration of operation, failed to increase recurrence-free period and 3 to 5 years survival of the patients. Specific features of combined interventions are described.

[A method for forming a urinary bladder from the sigmoid after radical cystectomy in patients with bladder cancer].

A procedure was evolved and tested for forming a urinary bladder from the sigmoid in the course of radical cystectomy carried out for invasive bladder cancer (20). A sigmo-sigmoid anastomosis ("end-to-side") was used by means of an apparatus suture.

[Possibilities of atorvastatin in complex management of extensive psoriasis in patients with arterial hypertension].

Efficacy and safety of the use of atorvastatin in complex treatment of extensive psoriasis was studied in 63 patients with psoriasis and arterial hypertension (AH). Complex clinical functional examination was carried out at study entry and after 6 months of treatment. Psoriasis severity was evaluated with PASI scale, quality of life with DLQI, PDI and SF 36 questionnaires.

[Influence of immunological parameters on the effectiveness of systemic and loco-regional immunotherapy in disseminated renal carcinoma].

Survival was assessed among patients with disseminated renal carcinoma from different prognostic groups as established by MSKCC protocol. Multivariate evaluation pointed to prognostic value of IL-6 (spontaneous and induced production), IL-8 (spontaneous and induced production),TNF-alpha (spontaneous production), IFN-gamma (induced production), TNK-cells (CD3+CD16+CD56+), and T-regulatory cells (CD4+CD25+Treg). It was demonstrated that additional criteria may be used to evaluate prognosis.

[Poorly differentiated prostate cancer may be associated with cytomegalovirus infection in prostatic tissue].

Polymerase chain-reaction procedure was used to test archival samples of prostate tissue from 90 cancer patients for cytomegalovirus infection detected in 46.7%. The median Gleason score and G-index (TNM classification) were significantly higher in CMV-positive patients (8 and 4, respectively) than those in CMV-negative ones (6 and 2, respectively).

[Specific features of hemostasis during radical retropubic prostatectomy].

From September 1999 through March 2008 radical retropubic prostatectomy (RRP) with bilateral pelvic lymphadenectomy was fulfilled in 148 male patients aged from 48 to 77 years, mean age 61 +/- 5.3 years. The patients were divided into 2 groups: the first group (63 patients) was subjected to RRP without using apparatus "LigaSure" and using either antegrade or retrograde technique RRP.

[Positron emission tomography with 18-fluorine deoxyglucose in the diagnosis and assessment of prostate cancer].

Results of PET studies using 18-fluorine deoxyglucose (18-FDG) in patients with large-size masses (51) are discussed. Histologically-confirmed prostate cancer was diagnosed in 36 (70.5%), benign hyperplasia--12 (23.

[Application of radiofrequency ablation for treatment of localized renal carcinoma].

An evaluation of the results of radiofrequency ablation of renal clear-cell carcinoma (pT1aN0M0) in 7 patients is presented. The longest follow-up was 26 months, the shortest--4 months. No complication was reported.

[Capacities of complex ultrasound study in the diagnosis of prostate cancer].

Prostate cancer (PC) constitutes the bulk of male small pelvic abnormalities. The early diagnosis of PC is the most topical problem in oncourology. At present, ultrasound imaging is common in the diagnosis of prostatic diseases.

[The frequency and diagnostic value of microscopic signs of minimal prostate adenocarcinoma].

Prostate biopsy specimens from 64 patients were studied. In most cases with minimal prostate adenocarcinoma, the tumor was limited by the organ and of moderate malignancy.

[Positron emission tomography in oncourology].

The authors present the results of the examination of 61 patients with genitourinary space-occupying lesions, using 18F- fluorodeoxyglucose positron emission tomography (PET) in whole body mode. In all cases the diagnosis was verified morphologically. The results demonstrated high diagnostic accuracy of PET, including possibility to determine the extent of oncourological cancer.

[Technical improvement of the prostate thick-needle biopsy].

The method is proposed for minimizing loss of material of needle biopsy of the prostate by means of a container during fixation. This allous (1) saving all the fragments, (2) to increase the surface of the material in the micropreparation and (3) to put into one paraffin block several columns and thus to decrease the cost of histological study.

[Gene expression profiles of protein kinases and phosphatases obtained by hybridization with cDNA arrays: molecular portrait of human prostate carcinoma].

Hybridization with cDNA arrays was used to obtain expression profiles of 263 protein-tyrosine kinase (PTK), protein-tyrosine phosphatase (PTP), dual-specific phosphatase (DuSP), and other genes for the normal prostate tissue, primary prostate carcinomas (PC) of 84 patients, 7 xenografts, and 5 carcinoma cell lines. Analysis of 96 profiles revealed eight clusters of genes coexpressed in PC (coefficient of correlation r > 0.7).

[Molecular portrait of human kidney carcinomas: the gene expression profiling of protein-tyrosine kinases and tyrosine phosphatases which controlled regulatory signals in the cells].

Hybridization with cDNA arrays was used to obtain expression profiles of 214 protein-tyrosine kinase, protein-tyrosine phosphatase, dual-specific phosphatase, and other genes for kidney carcinomas (KC) and normal kidney tissues of 34 patients and for seven carcinoma cell lines. Computer analysis revealed three clusters of genes coexpressed in KC. A proliferating-cell gene cluster included MET, VIM, MYC, TOP2A, PCNA, etc.

[The effectiveness of hyperbaric oxygenation in chronic obstructive bronchitis made in outpatient clinic].

General clinical examination, external respiratory function investigation, antrovent pharmacological tests were performed in 68 patients aged 28-52 years with chronic obstructive bronchitis (COB) admitted to the rehabilitation center after hospital treatment. Hyperbaric oxygenation improved general condition of the patients, normalized excessive free-radical lipid oxidation and antioxidant defense. It also improves the results of combined rehabilitation treatment, bronchial permeability, sensitivity of beta-2 bronchial receptors to sympathomimetics.

[Long-term results of endovascular treatment of metastatic renal cell cancer].

The authors analyse the long-term results of treatment of 106 patients with advanced renal cell carcinoma. The patients were divided in two groups. Group 1 (42 patients) included cases with single metastatic lesion.