[The effect of the morphofunctional state of the thrombocytes on the activation of destabilization processes in patients with acute forms of ischemic heart disease].

With the purpose of assessing the influence that platelet morphofunctional state may have on the degree of destabilization in patients with different forms of unstable angina we examined 198 patients using stress tests, Holter ECG monitoring, studying activation of thrombocytes with the aid of a luminescent-microscopy technique, and performing an analysis of aggregation. Important differences have been revealed in the studied parameters in those patients presenting with freshly detected and progressive stenocardia and with a developing, despite of the treatments administered, myocardial infarction, that might be caused by abnormal shifts in the thrombocyte intact/activated forms ratio.

[The use of the antioxidant trimetazidine (Preductal) in the combined therapy of acute myocardial infarct].

86 patients with acute transmural and macrofocal myocardial infarction received combined treatment which included standard therapy (thrombolytic drugs, beta-blockers, APP inhibitors, nitrates, aspirin) and antioxidant trimetasidine. The addition of the latter was beneficial: the size of the myocardial lesion was limited, electrical instability of the heart attenuated, early dilatation of the left heart prevented.

[The biorhythmology of primary and superinvasive opisthorchiasis. The seasonal variability in the relative mass of the parenchymatous and lymphoid organs in golden hamsters].

600 Golden Hamsters were divided into 3 groups: 1--free from opisthorchis invasion, 2--once infected, 3--repeatedly infected. Seasonal variability of liver, portal and mesentery lymph node and adrenal gland relative mass was investigated in winter, spring and autumn. Diurnal stereotype variability of parenchymatous and lymphoid organ relative mass is associated with a season and invasion number, and in a considerable degree is reflected in the meaning of average diurnal index.

[The data from clinical, instrumental and laboratory studies as markers in the prognosis of the restabilization process in patients with a history of unstable stenocardia].

With the purpose of preventing the development of acute clinical ischemic lesions of the myocardium, and their further progression, regression of coronary atherosclerosis the authors followed up for more than one year 250 patients with unstable stenocardia and singled out two groups of these patients, each group having important differences as to coronary reserve, functional state of the myocardium, lipid spectrum, dynamics of vasoactive substances, immunological reactivity, thrombocytic activity. Early detection of groups with an unfavourable course of IHD in patients with unstable stenocardia will allow to optimize treatment and avoid development of acute coronary catastrophies.

[Use of obzidan in the acute period of myocardial infarct].

Forty-four patients with acute myocardial infarction were given 0.15 mg/kg propranolol (obsidan) by intravenous drip, after which 80--160 mg of the drug were given daily by mouth for 4--5 days. The extent of the ischemic damage and the dynamics of the infarction zone were judged according to the results of electrocardiotopogram recorded from 35 leads and serial tests for creatine phosphokinase activity in blood serum.