Publications by Shizuka Kishimoto

Publications by authors named "Shizuka Kishimoto"

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Effect of oral ketoconazole on first-pass effect of nifedipine after oral administration in dogs.

Masanori Kuroha Hideki Kayaba Shizuka Kishimoto Waleed F Khalil Minoru Shimoda

J Pharm Sci

March 2002

The long-term oral ketoconazole (KTZ) treatment extensively inhibits hepatic CYP3A activity. We investigated the effect of the KTZ treatment on hepatic and intestinal extraction of nifedipine (NIF) using beagle dogs. Four dogs were given orally KTZ for 20 days (200 mg, bid).

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