Publications by Shizuho Minami

Publications by authors named "Shizuho Minami"

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Delayed Administration of BQ788, an ET Antagonist, after Experimental Traumatic Brain Injury Promotes Recovery of Blood-Brain Barrier Function and a Reduction of Cerebral Edema in Mice.

Shotaro Michinaga Akimasa Kimura Shunichi Hatanaka Shizuho Minami Arisa Asano

J Neurotrauma

July 2018

Article Synopsis

Traumatic brain injury (TBI) leads to significant brain damage, disability, and disruption of the blood-brain barrier (BBB), which contributes to complications like brain edema and neuroinflammation.
In a mouse study using lateral fluid percussion injury (FPI), researchers found that the endothelin-1 (ET-1) and its receptors increased after TBI, which correlated with worsening BBB dysfunction and brain edema.
Administering the endothelin antagonist BQ788 improved recovery from these effects by reversing the damage to BBB-protective proteins and reducing the presence of inflammatory astrocytes.

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Improvement of cold injury-induced mouse brain edema by endothelin ETB antagonists is accompanied by decreases in matrixmetalloproteinase 9 and vascular endothelial growth factor-A.

Shotaro Michinaga Naoki Seno Mayu Fuka Yui Yamamoto Shizuho Minami

Eur J Neurosci

September 2015

Brain edema is a potentially fatal pathological state that often occurs after brain injuries such as ischemia and trauma. However, therapeutic agents that fundamentally treat brain edema have not yet been established. We previously found that endothelin ETB receptor antagonists attenuate the formation and maintenance of vasogenic brain edema after cold injury in mice.