Publications by authors named "Shizhu Li"
Analysis of Severe and Relapse Risks of Imported Malaria in Five Provinces of China.
Am J Trop Med Hyg
December 2024
Although China has achieved malaria elimination certification, the risk of malaria transmission reintroduction due to imported malaria remains. We analyzed data on imported malaria cases collected from January 1, 2014 to December 31, 2021, using multivariable logistic regression analysis to identify the factors associated with severe and relapsing malaria. The odds of severe malaria were around 4-fold greater for patients who were initially diagnosed with a nonmalarial illness than for patients initially diagnosed with malaria.
View Article and Find Full Text PDFIntroduction: The WHO aims to eliminate schistosomiasis as a public health problem by 2030. Based on the Global Burden of Disease 2021 (GBD 2021), this study assesses the global distribution of schistosomiasis burden to guide policy and resource allocation.
Methods: Schistosomiasis burden and social-demographic indexes (SDIs) data were extracted from GBD 2021 study.
Background: The emergence of dengue fever has prompted significant public health responses, highlighting the need for a comprehensive understanding of One Health in addressing vector-borne diseases. China's experience in dengue control and prevention programs offers valuable insights into the successful integration of multidisciplinary strategies.
Aims: The review aims to: (1) systematically analyze lessons from China's dengue control and prevention programs, focusing on the integration of these efforts with the One Health approach; (2) underscore the reasons of optimizing the dengue control and prevention program; (3) highlight the alignment of China's dengue control strategies with the One Health framework; (4) contribute to global efforts in combating dengue, providing scientific evidence and strategic recommendations for other regions facing similar challenges.
Article Synopsis
- The study focused on sequencing the complete mitochondrial genome of Oncomelania hupensis robertsoni, the sole intermediate host for Schistosoma japonicum in southwestern China, to understand its genetic variation.
- A total of 26 mitochondrial sequences were obtained, with genomes ranging from 15,181 to 15,187 base pairs and including 37 genes (13 protein-coding, 2 rRNA, and 22 tRNA).
- Findings revealed the presence of different strains of Oncomelania hupensis robertsoni, specifically the Yunnan and Sichuan strains, with the Yunnan strain further divided into northern and southern sub-branches, highlighting significant genetic differentiation in the species.
Article Synopsis
- - Visceral leishmaniasis (VL) is a significant disease in central and western China, transmitted by sandflies and affecting both people and animals.
- - Recent findings reveal VL hotspots in several border areas and a rapid increase in mountain zoonotic visceral leishmaniasis (MT-ZVL) in multiple provinces from 2011 to 2022, with 671 cases reported in historically affected areas.
- - To combat the spread of MT-ZVL, public health recommendations include implementing One Health strategies, enhancing surveillance for sandflies and infected dogs, and ensuring timely diagnosis and treatment for patients.
Article Synopsis
- Upper respiratory infections (URIs) are prevalent worldwide, making it essential for governments to understanding their impact for effective healthcare planning and resource allocation.
- An analysis of the GBD 2021 data showed a significant decline in various URI metrics (incidence, prevalence, mortality, and disability) from 1990 to 2021, particularly affecting the elderly and young children.
- Future projections indicate a rise in URI incidence and prevalence from 2022 to 2050, while mortality rates are expected to decline, highlighting ongoing public health challenges, especially related to factors like low birth weight.
Article Synopsis
- Soil-transmitted helminth (STH) infections affect approximately 1.5 billion people globally, predominantly in tropical and subtropical areas, with a study conducted to analyze trends from 1990 to 2021.
- In 2021, there were around 642.72 million STH cases worldwide, with the highest prevalence in children aged 5-9 years, and a noticeable decline in infection rates over time.
- The study found a significant negative correlation between the prevalence of STH infections and socio-demographic index (SDI), indicating that regions with lower socio-economic status tend to have higher infection rates and associated disability-adjusted life-years (DALYs).
Article Synopsis
- A 30-year-old pregnant woman in Shandong Province, China, was diagnosed with a persistent high fever, and high-throughput sequencing identified the presence of the parasite Trypanosoma dionisii in her blood.
- The patient showed symptoms like fever and respiratory issues but made a full recovery without long-term effects; genetic analysis revealed her infection was closely related to T. dionisii found in local bats.
- This case highlights T. dionisii as a potential zoonotic pathogen, emphasizing the risk of its transmission from wildlife, particularly rodents and bats, to humans.
The aim of this review was to delve into the extent of mosquito virome coverage (proportion of viral reads) via meta-viromic sequencing and uncover potential factors of heterogeneity that could impact this coverage. Data sources were PubMed, Web of Science, Embase, Scopus, Science-Direct, Google Scholar, and the China National Knowledge Infrastructure. Pooled coverage was estimated using random-effects modeling, and subgroup analyses further reveal potential heterogeneous factors.
View Article and Find Full Text PDFArticle Synopsis
- Schistosomiasis is a significant health challenge in sub-Saharan Africa, where 95% of global cases are found, leading to an increased demand for praziquantel (PZQ) for treatment among all age groups at risk.
- The study analyzed research from 1991 to 2022 to determine the relationship between the prevalence of schistosomiasis in humans and its presence in intermediate snail hosts, using a statistical model for pooled prevalence estimates.
- Results indicated that schistosomiasis affects about 27.5% of humans, with certain snail species demonstrating infection rates of 8.6%, and a modest correlation (0.3) was found between infections in snails and humans, suggesting snails could
Article Synopsis
- - In 2021, China was declared malaria-free by the WHO, yet there remains a public health issue with severe cases of imported malaria arising from globalization, prompting a study on its epidemiology from 2014 to 2021 in five provinces.
- - Researchers analyzed data from 5,559 malaria cases, finding that Plasmodium falciparum was the most prevalent species, predominantly affecting males, with significant complication rates linked to specific factors.
- - The study identified protective factors against malaria complications, such as previous infections, while increased age, misdiagnosis, and longer treatment delays were highlighted as risk factors, supporting the need for improved prevention strategies.
Article Synopsis
- * Utilizing data from the Global Burden of Disease Study 2021, the research analyzed trends in incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for various forms of HIV-related TB from 1990 to 2021.
- * In 2021, the rates showed that HIV-DS-TB had the highest incidence and mortality rates compared to HIV-MDR-TB and HIV-XDR-TB, with significant increases in the incidence and mortality of multi-drug resistant and extensively drug-resistant forms over the study
Article Synopsis
- The One Health approach integrates human, animal, and environmental health, promoting interdisciplinary collaboration to tackle global health challenges and requiring new assessment tools for effective implementation.
- The enhanced Global One Health Index (GOHI) 2022 employs a comprehensive system of indices and sub-indicators, using a fuzzy analytic hierarchy process to analyze data across 160 countries/territories and provide insights into global health performance.
- GOHI 2022 reveals significant disparities in health scores across regions, with a global average of 54.82, indicating that North America and Europe score higher, while antimicrobial resistance ranks as a notable weakness within the One Health framework.
China's One Health governance system: the framework and its application.
Sci One Health
September 2023
One Health is an interdisciplinary approach that promotes the resolution of complex health issues through collaboration across multiple disciplines. In addition to accountability, the One Health governance structure fosters shared understanding, trust, and an appreciation for diverse perspectives and requirements. This article provides a comprehensive analysis of the current integration of the One Health approach within China's existing health governance framework.
View Article and Find Full Text PDFOrientation of One Health development: think globally and act locally.
Sci One Health
September 2023
One Health is dedicated to maintaining and fostering a dynamic balance among humans, animals, and the environment. Since 2013, it has seen considerable developments globally. This review aims to encapsulate the history of One Health, as well as chart its future trajectory.
View Article and Find Full Text PDFArticle Synopsis
- - The study focuses on Oncomelania hupensis, the snail that acts as an intermediate host for Schistosoma japonicum in China, and examines how levees along the Yangtze River have impacted its distribution over time.
- - Researchers used GPS and historical records to track the habitats of the snails, analyzing data to understand the changes in their populations and geographical distribution before and after the construction of the levees.
- - Findings revealed that while the infestation area initially increased, it declined significantly outside the Yangtze River after 1970, highlighting the influence of environmental changes on the snail's spread.
Background: Schistosomiasis japonica represents a significant public health concern in South Asia. There is an urgent need to optimize existing schistosomiasis diagnostic techniques. This study aims to develop models for the different stages of liver fibrosis caused by Schistosoma infection utilizing ultrasound radiomics and machine learning techniques.
View Article and Find Full Text PDFObjective: To understand the epidemiological distribution characteristics of mountain-type zoonotic visceral leishmaniasis (MT-ZVL) in Yangquan City, Shanxi Province, China, from 2006 to 2021, to explore the influencing factors leading to the re-emergence of the epidemic, and to provide a basis for the formulation of targeted control strategies.
Methods: Case information spanning from 2006 to 2021 in Yangquan City was collected for a retrospective case-control study conducted from June to September 2022. A 1:3 matched ratio was employed.
What Is Already Known About This Topic?: China's "1-3-7" approach outlines specific targets to guide and monitor the processes of case reporting, investigation, and response. However, few studies have examined the time intervals preceding the initial step, and the timeline from the arrival of imported malaria cases in China to their diagnosis has been largely overlooked.
What Is Added By This Report?: The study demonstrated that the median duration from arrival in China to the onset of symptoms for was 78 days, with 71.
Background: The elimination of schistosomiasis remains a challenging task, with current measures primarily focused on the monitoring and control of Oncomelania hupensis (O. hupensis) snail, the sole intermediate host of Schistosome japonicum. Given the emerging, re-emerging, and persistent habitats of snails, understanding their genetic diversity might be essential for their successful monitoring and control.
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- Anhui Province is experiencing an increase in imported malaria cases due to globalization, prompting the implementation of a comprehensive framework to combat the issue.
- A study collected data from 2012 to 2022, revealing that out of 1,008 reported cases, some faced delays in diagnosis while factors like age, occupation, and initial misdiagnosis were linked to severe malaria.
- The adaptive framework improved health responses, achieving 100% rates for timely medical visits and species identification, while timely diagnosis reached 78.57%, showcasing its effectiveness against imported malaria.
Background: Schistosoma japonicum is a parasitic flatworm that causes human schistosomiasis, which is a significant cause of morbidity in China, the Philippines and Indonesia. Oncomelania hupensis (Gastropoda: Pomatiopsidae) is the unique intermediate host of S. japonicum.
View Article and Find Full Text PDFObjective: Precision interventions have been proposed in transmission-interrupted areas to further reduce the potential transmission risk of schistosomiasis. This study aimed to evaluate the effects of different interventions modes for potential transmission risk control.
Methods: Three groups of schistosomiasis-endemic villages were selected in Jiangling county, Hubei province.
Morphological and transcriptional analysis of sexual differentiation and gonadal development in a burrowing fish, the four-eyed sleeper (Bostrychus sinensis).
Comp Biochem Physiol Part D Genomics Proteomics
December 2023
Article Synopsis
- The study focuses on the four-eyed sleeper fish, a commercially important species, exploring the advantages of producing all-male progeny for economic gain.
- Researchers investigated the stages of gonadal development and identified crucial time points for sexual differentiation, especially in germ stem cells.
- Transcriptome analysis uncovered key genes and signaling pathways related to sexual differentiation, laying the groundwork for potential sex-control strategies in aquaculture.