Silencing of mitigates the proliferation and migration of vascular smooth muscle cells and vascular intimal hyperplasia by suppressing STAT3/DRP1-mediated mitochondrial fission.

The pathological proliferation and migration of vascular smooth muscle cells (VSMCs) are key processes during vascular neointimal hyperplasia (NIH) and restenosis. Phosphoenolpyruvate carboxy kinase 1 (PCK1) is closely related to a variety of malignant proliferative diseases. However, the role of PCK1 in VSMCs has rarely been investigated.

Experimental Investigation on the Influence of Wave Impedance on Dynamic Mechanical Response of Granites undergone High Temperature.

Wave impedance is an important physical quantity to characterize the dynamic properties of materials. To explore the influence of wave impedance on the dynamic mechanical response of rock, the granite samples with a wave impedance gradient change are obtained by changing the heating temperature, and the impact compression test is carried out by using a split Hopkinson pressure bar (SHPB) device. The stress wave propagation law, dynamic stress-strain relationship, and fracture characteristics of rocks with different wave impedances are studied comparatively, and the influence mechanism of wave impedance on the dynamic mechanical response of rocks is comprehensively analyzed from two aspects of material properties and dynamics.