Publications by authors named "Shizhen Yuan"
Article Synopsis
- Obstructive sleep apnea (OSA) is linked to sleep and psychological disorders, and the study investigates how brain asymmetry (BA) relates to these conditions in OSA patients.
- The research involved 152 OSA and 21 non-OSA subjects, measuring brain activity during rest and sleep, and assessing psychological traits and clinical characteristics.
- Findings indicate that OSA is associated with increased brain asymmetry, particularly in the right hemisphere, which correlates with traits like anxiety and extraversion, suggesting that sleep disturbances can affect psychological well-being.
Purpose: This study aimed to investigate the association between sleep spindle metrics and executive function in individuals with obstructive sleep apnea (OSA). Furthermore, we examined the association of age and education on executive function.
Patients And Methods: A total of 230 (40.
Background: The structural changes of gastric mucosa are considered as an important window of early gastric lesions. This article shows an imaging method of the stomach that does not use imaging agents. X-ray phase-contrast images of different stages of gastric development were taken using micrometer level X-ray in-line phase-contrast imaging (XILPCI) technique on synchrotron radiation facility.
View Article and Find Full Text PDFA sulfur coordination polymer with wide bandgap semiconductivity formed from zinc(II) and 5-methylsulfanyl-1,3,4-thiadiazole-2-thione.
Acta Crystallogr C Struct Chem
September 2019
The sulfur coordination polymer catena-poly[zinc(II)-μ-bis[5-(methylsulfanyl)-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-ido-κN:S]], [Zn(CHNS)] or [ZnMTT], constructed from Zn ions and 5-methylsulfanyl-1,3,4-thiadiazole-2-thione (HMTT), was synthesized successfully and structurally characterized. [ZnMTT] crystallizes in the tetragonal space group I-4 (No. 82).
View Article and Find Full Text PDF[Experimental study of MAT1 gene silencing mediated by siRNA in pancreatic cancer].
Zhonghua Yi Xue Za Zhi
October 2007
Objective: To investigate the inhibitory effect of gene silencing mediated by MAT1-siRNA constructed in vitro transcription for pancreatic cancer in vivo and in vitro.
Methods: 21-nt double strand siRNA targeting MAT1 gene was constructed and labeled with Cy3 fluorescent labeling reagent. Human pancreatic cancer cells of the line BxPC3 were cultured and divided into 4 groups: MAT1-siRNA transfected group, negative siRNA control group, lipid control group, and blank control group.
Background & Objective: NK4 is not only an antagonist of hepatocyte growth factor but also an angiogenesis inhibitor. Studies have confirmed that NK4 can inhibit tumor growth and metastasis, but its effect on pancreatic cancer remains unknown. This study was designed to observe the effect of NK4 gene on human pancreatic cancer in nude mice and the possible mechanisms.
View Article and Find Full Text PDFObjective: To investigate the regulatory effect of the human MAT1 gene on the cell cycle G(1)/S transition of human pancreatic cancer BxPC-3 cells.
Methods: To construct the replication deficient recombinant adenovirus of antisense MAT1 gene using homologous recombination by AdEasy system. Cell growth assay was carried out by counting alive cells after trypan blue exclusion.
Antiangiogenic therapy for human pancreatic carcinoma xenografts in nude mice.
World J Gastroenterol
January 2005
Aim: To investigate the anti-tumor effects of antiangiogenic therapy (a combination of TNP-470, an antiangiogenic compound, with gemcitabine, an antimetabolite) on human pancreatic carcinoma xenografts and its mechanism.
Methods: A surgical orthotopic implantation (SOI) model was established by suturing small pieces of SW1990 pancreatic carcinoma into the tail of pancreas in nude male mice. Mice then received either single therapy (n = 24) or combined therapy (n = 32).
Background & Objective: Hepatocyte growth factor (HGF) plays an important role in the regulation of migration, invasion,and angiogenesis of cancer via the activation of its receptor, c-Met. NK4 is not only an antagonist of HGF but also an angiogenesis inhibitor. The blockade of HGF/c-Met signal pathway and tumor angiogenesis may be a new strategy for cancer treatment.
View Article and Find Full Text PDFExperimental study of gene therapy with angiostatin gene in pancreatic cancer.
Hepatobiliary Pancreat Dis Int
August 2002
Article Synopsis
- The study aimed to explore how the angiostatin (AS) gene affects pancreatic cancer cells (specifically SW1990) when delivered via liposomes.
- Researchers cloned the AS gene into a vector (pRC/CMV) and introduced it into the cancer cells to assess its anti-tumor mechanism.
- Results showed that the AS vector was successfully integrated into the cells, inhibited blood vessel growth, and reduced tumor size in mice, suggesting its potential as a future treatment for pancreatic cancer.
Expression of c-erbB-2 oncogene protein, epidermal growth factor receptor, and TGF-beta1 in human pancreatic ductal adenocarcinoma.
Hepatobiliary Pancreat Dis Int
November 2002
Objective: To detect the relations of c-erbB-2 oncogene protein, epidermal growth factor receptor (EGFR) and transforming growth factor-beta1 (TGF-beta1) to the progression or metastasis of pancreatic carcinoma.
Methods: Using streptavidinbiotin complex (SABC) method, c-erbB-2 oncongene protein, we examined immunohistochemically EGFR and TGF-beta1 expressions in wax-tissue sections from 10 individuals with normal pancreas (NP), 13 patients with chronic pancreatitis (CP) and 36 patients with pancreatic ductal adenocarcinoma (PC).
Results: The positive expression rates of c-cerbB-2 oncogene protein, EGFR and TGF-beta1 in the NP, CP and PC groups were 0, 0, 10%; 7.